| Involvement of extracellular superoxide dismutase in regulating brain blood flow. | |
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MedLine Citation:
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PMID: 20033309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The physiological role of extracellular superoxide dismutase (SOD3) has received insufficient study. We investigated the hypothesis that SOD3, which neutralizes superoxide anions (O2(-)) in the intercellular space of the brain, prevents the inactivation of nitric oxide (NO) and is thus involved in regulating cerebral vascular tone. Local brain blood flow was measured in the striatum of anesthetized rats during administration of various combinations of a SOD mimetic, a SOD inhibitor, an NO donor, and an NOS inhibitor into the striatum using a Hamilton syringe. In normal conditions, SOD3 was found to minimize O2(-) levels, protecting endogenously produced NO at a sufficient level to maintain cerebral vascular tone and reactivity. SOD3 was found to increase the vasodilatory effect of endogenously produced NO in the brain. SOD3 was found to neutralize superoxide anions produced in the brain during respiration of 100% O2 and to maintain basal NO levels and its vasodilatory potential in normobaric hyperoxia. |
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Authors:
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I T Demchenko; D R Gutsaeva; A N Moskvin; S Yu Zhilyaev |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-22 |
Journal Detail:
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Title: Neuroscience and behavioral physiology Volume: 40 ISSN: 1573-899X ISO Abbreviation: Neurosci. Behav. Physiol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330471 Medline TA: Neurosci Behav Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 173-8 Citation Subset: IM |
Affiliation:
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I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, 44 M. Torez Prospekt, 194223 St. Petersburg, Russia. jil@iephb.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessels / drug effects, enzymology, physiology Brain / blood supply*, drug effects, physiology* Cerebrovascular Circulation / drug effects, physiology* Corpus Striatum / blood supply, drug effects, physiology Enzyme Inhibitors / pharmacology Extracellular Space / drug effects, physiology Hyperoxia / metabolism NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / metabolism Nitric Oxide Donors / pharmacology Nitric Oxide Synthase / antagonists & inhibitors, metabolism Rats S-Nitroso-N-Acetylpenicillamine / pharmacology Superoxide Dismutase / antagonists & inhibitors, metabolism* Superoxides / metabolism Vasodilation / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Nitric Oxide Donors; 10102-43-9/Nitric Oxide; 11062-77-4/Superoxides; 50903-99-6/NG-Nitroarginine Methyl Ester; 79032-48-7/S-Nitroso-N-Acetylpenicillamine; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.15.1.1/Sod3 protein, rat; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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