Document Detail

Involucrin in squamous and basal cell carcinomas of the skin: an immunohistochemical study.
MedLine Citation:
PMID:  6210326     Owner:  NLM     Status:  MEDLINE    
Involucrin is a precursor of cross-linked protein of human stratum corneum, and its appearance in the upper layers of the epidermis is a function of the normal differentiation of the keratinocyte. Cases of basal cell and squamous cell carcinoma were evaluated for the presence of involucrin using immunoperoxidase techniques on paraffin sections. Basal cell carcinomas were negative for involucrin with staining restricted to squamous horn cysts, while squamous cell carcinomas stained strongly, particularly in large keratinized cells. Cases of squamous cell carcinoma in situ (Bowen's disease) revealed increased staining for involucrin with staining of dyskeratotic cells at all levels in the epithelium. Abnormal patterns of staining were also noted in non-neoplastic epidermis adjacent to carcinomas. Immunohistochemical staining for involucrin identifying abnormal or premature keratinization is a sensitive marker for dyskeratosis in squamous epithelia and may have applications in the histopathologic evaluation of skin specimens.
J W Said; A F Sassoon; I P Shintaku; S Banks-Schlegel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  82     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1984 May 
Date Detail:
Created Date:  1985-01-28     Completed Date:  1985-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  449-52     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Basal Cell / metabolism*
Carcinoma, Squamous Cell / metabolism*
Epidermis / metabolism
Immunoenzyme Techniques
Keratins / metabolism
Protein Precursors / metabolism*
Skin Neoplasms / metabolism*
Reg. No./Substance:
0/Protein Precursors; 60108-77-2/involucrin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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