Document Detail


Involucrin in squamous and basal cell carcinomas of the skin: an immunohistochemical study.
MedLine Citation:
PMID:  6210326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Involucrin is a precursor of cross-linked protein of human stratum corneum, and its appearance in the upper layers of the epidermis is a function of the normal differentiation of the keratinocyte. Cases of basal cell and squamous cell carcinoma were evaluated for the presence of involucrin using immunoperoxidase techniques on paraffin sections. Basal cell carcinomas were negative for involucrin with staining restricted to squamous horn cysts, while squamous cell carcinomas stained strongly, particularly in large keratinized cells. Cases of squamous cell carcinoma in situ (Bowen's disease) revealed increased staining for involucrin with staining of dyskeratotic cells at all levels in the epithelium. Abnormal patterns of staining were also noted in non-neoplastic epidermis adjacent to carcinomas. Immunohistochemical staining for involucrin identifying abnormal or premature keratinization is a sensitive marker for dyskeratosis in squamous epithelia and may have applications in the histopathologic evaluation of skin specimens.
Authors:
J W Said; A F Sassoon; I P Shintaku; S Banks-Schlegel
Related Documents :
3615636 - Strategies for selective cancer photochemotherapy: antibody-targeted and selective carc...
8649826 - P16 inhibition of transformed and primary squamous epithelial cells.
8411256 - Xenograft model of progressive human proliferative breast disease.
21524346 - Mechanism of t cell exhaustion in a chronic environment.
22535206 - Quantitative analysis of energy metabolic pathways in mcf-7 breast cancer cells by sele...
9394016 - T cell syncytia induced by hiv release. t cell chemoattractants: demonstration with a n...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  82     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1984 May 
Date Detail:
Created Date:  1985-01-28     Completed Date:  1985-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  449-52     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Carcinoma, Basal Cell / metabolism*
Carcinoma, Squamous Cell / metabolism*
Epidermis / metabolism
Histocytochemistry
Humans
Immunoenzyme Techniques
Keratins / metabolism
Protein Precursors / metabolism*
Skin Neoplasms / metabolism*
Chemical
Reg. No./Substance:
0/Protein Precursors; 60108-77-2/involucrin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Demonstration of anti-keratin antibodies by ELISA using keratin or thiol-containing compounds in ure...
Next Document:  Keratin intermediate filaments bear antigenic determinants for stratum corneum antibodies.