Document Detail

Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis.
MedLine Citation:
PMID:  19760617     Owner:  NLM     Status:  In-Data-Review    
It has been reported that microcystins (MCs) could accumulate in the gonads of mammals and MCs exposure exerts obvious toxic effects on male reproductive system of mammals. We have comfirmedthat MCs could accumulate and induce apoptosis in rat testis. The p53, Bax, and Bcl-2 protein play important roles in mitochondria-dependent apoptotic pathway, and this study aimed to investigate whether the p53, Bax, and Bcl-2 pathway is involved in microcystins-induced apoptosis in rat testis and discussed the possible mechanisms. Our results show that MCs led to persistent increase of transcriptional and protein level of P53 and Bax expression but led to decrease of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which might contribute to apoptotic cell death of rat testis following MCs treatment. The increased ratio of expression of Bax to that of Bcl-2 induced by MCs suggests their important role in MCs-induced apoptosis in rat testis tissue. © 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 111-117, 2011.
Guang-Yu Li; Ping Xie; Hui-Ying Li; Le Hao; Qian Xiong; Tong Qiu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental toxicology     Volume:  26     ISSN:  1522-7278     ISO Abbreviation:  Environ. Toxicol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100885357     Medline TA:  Environ Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Wiley Periodicals, Inc.
Donghu Experimental Station of Lake Ecosystems, State Key Laboratory for Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, The Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, People's Republic of China.
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