| Invivo pharmacokinetics of the antitumor agent 4,6-benzylidene-d-glucose (bg) and a deuterated analog 4,6-benzylidene-d1-d-glucose (p-1013) in mice, rats and dogs. | |
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MedLine Citation:
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PMID: 21573515 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In vivo pharmacokinetics of the antitumour agent 4,6-benzylidene-D-glucose (BG) and a deuterated analog 4,6-benzylidene-d1-D-glucose (P-1013) were investigated in athymic mice, Beagle dogs and Wistar rats following i.v. administration of the compounds. Reverse-phase high performance liquid chromatography (HPLC) was used to quantitate drug and metabolite content in plasma samples. No difference in the half-life (t1/2) for BG and P-1013 was observed in any of the three species, the half-lives were on the order of 10 min. Metabolism of BG and P-1013 leads to formation of undeuterated and deuterated 1,3-benzylidene-D-glucitol, respectively, as the only detectable metabolites. The half-lives of these metabolites were also measured and were found to differ between rats given undeuterated and deuterated drug. In mice and dogs the t1/2 was the same for deuterated and undeuterated 1,3-benzylidene-D-glucitol. |
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Authors:
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C Dunsaed; J Dornish; T Aastveit; E Pettersen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of oncology Volume: 2 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 1993 Jan |
Date Detail:
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Created Date: 2011-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: Greece |
Other Details:
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Languages: eng Pagination: 61-6 Citation Subset: - |
Affiliation:
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PRONOVA AS,DEPT PHARMACOL,N-0371 OSLO,NORWAY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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