Document Detail


Tumor necrosis factor-α: regulation of renal function and blood pressure.
MedLine Citation:
PMID:  23515717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine that becomes elevated in chronic inflammatory states such as hypertension and diabetes and has been found to mediate both increases and decreases in blood pressure. High levels of TNF-α decrease blood pressure, whereas moderate increases in TNF-α have been associated with increased NaCl retention and hypertension. The explanation for these disparate effects is not clear but could simply be due to different concentrations of TNF-α within the kidney, the physiological status of the subject, or the type of stimulus initiating the inflammatory response. TNF-α alters renal hemodynamics and nephron transport, affecting both activity and expression of transporters. It also mediates organ damage by stimulating immune cell infiltration and cell death. Here we will summarize the available findings and attempt to provide plausible explanations for such discrepancies.
Authors:
Vanesa D Ramseyer; Jeffrey L Garvin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-03-20
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  304     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-16     Completed Date:  2013-07-22     Revised Date:  2014-05-16    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F1231-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology*
Hemodynamics / physiology
Humans
Hypertension / metabolism,  physiopathology*
Kidney / physiology*
Tumor Necrosis Factor-alpha / physiology*
Grant Support
ID/Acronym/Agency:
HL-028982/HL/NHLBI NIH HHS; HL-070985/HL/NHLBI NIH HHS; HL-090550/HL/NHLBI NIH HHS; R01 HL070985/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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