Document Detail


Heme oxygenase, a novel target for the treatment of hypertension and obesity?
MedLine Citation:
PMID:  22071158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heme oxygenase (HO) is the rate-limiting enzyme in the metabolism of heme-releasing bioactive molecules carbon monoxide (CO), biliverdin, and iron, each with beneficial cardiovascular actions. Biliverdin is rapidly reduced to bilirubin, a potent antioxidant, by the enzyme biliverdin reductase, and iron is rapidly sequestered by ferritin in the cell. Several studies have demonstrated that HO-1 induction can attenuate the development of hypertension as well as lower blood pressure in established hypertension in both genetic and experimental models. HO-1 induction can also reduce target organ injury and can be beneficial in cardiovascular diseases, such as heart attack and stroke. Recent studies have also identified a beneficial role for HO-1 in the regulation of body weight and metabolism in diabetes and obesity. Chronic HO-1 induction lowers body weight and corrects hyperglycemia and hyperinsulinemia. Chronic HO-1 induction also modifies the phenotype of adipocytes in obesity from one of large, cytokine producing to smaller, adiponectin producing. Finally, chronic induction of HO-1 increases oxygen consumption, CO(2), and heat production and activity in obese mice. This review will discuss the current understanding of the actions of the HO system to lower blood pressure and body weight and how HO or its metabolites may be ideal candidates for the development of drugs that can both reduce blood pressure and lower body weight.
Authors:
Peter A Hosick; David E Stec
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-11-09
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  302     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-04     Completed Date:  2012-02-17     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R207-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / physiology
Energy Metabolism / physiology
Heme Oxygenase (Decyclizing) / metabolism*
Humans
Hypertension / enzymology*,  therapy
Obesity / enzymology*,  therapy
Grant Support
ID/Acronym/Agency:
1T32-HL-105324/HL/NHLBI NIH HHS; HL-088421/HL/NHLBI NIH HHS; R01 HL088421/HL/NHLBI NIH HHS; R01 HL088421-01A2/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 1.14.99.3/Heme Oxygenase (Decyclizing)
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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