Document Detail


Drosophila provides rapid modeling of renal development, function, and disease.
MedLine Citation:
PMID:  20926630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The evolution of specialized excretory cells is a cornerstone of the metazoan radiation, and the basic tasks performed by Drosophila and human renal systems are similar. The development of the Drosophila renal (Malpighian) tubule is a classic example of branched tubular morphogenesis, allowing study of mesenchymal-to-epithelial transitions, stem cell-mediated regeneration, and the evolution of a glomerular kidney. Tubule function employs conserved transport proteins, such as the Na(+), K(+)-ATPase and V-ATPase, aquaporins, inward rectifier K(+) channels, and organic solute transporters, regulated by cAMP, cGMP, nitric oxide, and calcium. In addition to generation and selective reabsorption of primary urine, the tubule plays roles in metabolism and excretion of xenobiotics, and in innate immunity. The gene expression resource FlyAtlas.org shows that the tubule is an ideal tissue for the modeling of renal diseases, such as nephrolithiasis and Bartter syndrome, or for inborn errors of metabolism. Studies are assisted by uniquely powerful genetic and transgenic resources, the widespread availability of mutant stocks, and low-cost, rapid deployment of new transgenics to allow manipulation of renal function in an organotypic context.
Authors:
Julian A T Dow; Michael F Romero
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-06
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  299     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-01-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F1237-44     Citation Subset:  IM    
Affiliation:
Institute of Cell, Molecular, and Systems Biology, College of Medical, Veterinary, and Life Sciences, Univ. of Glasgow, Glasgow G12 8QQ, UK. Julian.Dow@glasgow.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Cilia / physiology
Disease Models, Animal
Drosophila / physiology*
Drosophila Proteins / genetics
Humans
Ion Transport
Kidney / growth & development,  physiology*
Kidney Diseases / physiopathology*
Malpighian Tubules / physiology*
Metabolism, Inborn Errors / physiopathology
Models, Animal
Nephrolithiasis / genetics
Organogenesis
Vacuolar Proton-Translocating ATPases / genetics
Grant Support
ID/Acronym/Agency:
DK083007/DK/NIDDK NIH HHS; EY017732/EY/NEI NIH HHS; //Biotechnology and Biological Sciences Research Council
Chemical
Reg. No./Substance:
0/Drosophila Proteins; EC 3.6.1.-/Vacuolar Proton-Translocating ATPases
Comments/Corrections

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