| Drosophila provides rapid modeling of renal development, function, and disease. | |
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MedLine Citation:
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PMID: 20926630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evolution of specialized excretory cells is a cornerstone of the metazoan radiation, and the basic tasks performed by Drosophila and human renal systems are similar. The development of the Drosophila renal (Malpighian) tubule is a classic example of branched tubular morphogenesis, allowing study of mesenchymal-to-epithelial transitions, stem cell-mediated regeneration, and the evolution of a glomerular kidney. Tubule function employs conserved transport proteins, such as the Na(+), K(+)-ATPase and V-ATPase, aquaporins, inward rectifier K(+) channels, and organic solute transporters, regulated by cAMP, cGMP, nitric oxide, and calcium. In addition to generation and selective reabsorption of primary urine, the tubule plays roles in metabolism and excretion of xenobiotics, and in innate immunity. The gene expression resource FlyAtlas.org shows that the tubule is an ideal tissue for the modeling of renal diseases, such as nephrolithiasis and Bartter syndrome, or for inborn errors of metabolism. Studies are assisted by uniquely powerful genetic and transgenic resources, the widespread availability of mutant stocks, and low-cost, rapid deployment of new transgenics to allow manipulation of renal function in an organotypic context. |
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Authors:
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Julian A T Dow; Michael F Romero |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-10-06 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: 299 ISSN: 1522-1466 ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-08 Completed Date: 2011-01-10 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
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Languages: eng Pagination: F1237-44 Citation Subset: IM |
Affiliation:
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Institute of Cell, Molecular, and Systems Biology, College of Medical, Veterinary, and Life Sciences, Univ. of Glasgow, Glasgow G12 8QQ, UK. Julian.Dow@glasgow.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Cilia / physiology Disease Models, Animal Drosophila / physiology* Drosophila Proteins / genetics Humans Ion Transport Kidney / growth & development, physiology* Kidney Diseases / physiopathology* Malpighian Tubules / physiology* Metabolism, Inborn Errors / physiopathology Models, Animal Nephrolithiasis / genetics Organogenesis Vacuolar Proton-Translocating ATPases / genetics |
| Grant Support | |
ID/Acronym/Agency:
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DK083007/DK/NIDDK NIH HHS; EY017732/EY/NEI NIH HHS; //Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; EC 3.6.1.-/Vacuolar Proton-Translocating ATPases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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