Document Detail

Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas.
MedLine Citation:
PMID:  7701004     Owner:  NLM     Status:  MEDLINE    
Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D, and cycloheximide has served to determine the mechanism of action in relationship with that of glucocorticoids. Betulinic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.
M C Recio; R M Giner; S Máñez; J Gueho; H R Julien; K Hostettmann; J L Ríos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  61     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-04-28     Completed Date:  1995-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.
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MeSH Terms
Anti-Inflammatory Agents / pharmacology*
Plants, Medicinal / chemistry*
Triterpenes / pharmacology*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Steroids; 0/Triterpenes; 472-15-1/betulinic acid; 473-98-3/betulin; 77-52-1/ursolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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