| Investigations on metabolites of vitamin D in rat bile. Separation and partial identification of a major metabolite. | |
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MedLine Citation:
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PMID: 4311438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Young rats with cannulated bile ducts were given 0.34mg. of [1alpha-(3)H]cholecalciferol or 0.54mg. of [(14)C]ergocalciferol by intravenous infusion. Of the radioactivity in the dose of [1alpha-(3)H]cholecalciferol 31% was recovered in bile within 24hr. 2. The metabolites in bile were separated by gradient-elution column chromatography on silicic acid into five components, all more polar than cholecalciferol or 25-hydroxycholecalciferol. [(14)C]Ergocalciferol gave a similar pattern of metabolites in bile. 3. The three most polar metabolites were shown to be ionic. The major component has been identified as a glucuronide conjugate, which was not identical with synthetic cholecalciferyl glucuronide. |
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Authors:
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P A Bell; E Kodicek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 115 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1969 Dec |
Date Detail:
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Created Date: 1970-01-24 Completed Date: 1970-01-24 Revised Date: 2010-09-13 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 663-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / analysis* Carbon Isotopes Cholecalciferol / metabolism Chromatography Ergocalciferols / metabolism Female Glucuronates / analysis Glucuronidase Male Rats Silicon Dioxide Tritium Vitamin D / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Ergocalciferols; 0/Glucuronates; 10028-17-8/Tritium; 1406-16-2/Vitamin D; 67-97-0/Cholecalciferol; 7631-86-9/Silicon Dioxide; EC 3.2.1.31/Glucuronidase |
| Comments/Corrections | |
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