| Investigations into the mechanisms of coronary vasodilation by contrast media in dogs. | |
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MedLine Citation:
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PMID: 8877492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: The study was performed to clarify the mechanisms underlying contrast-induced coronary vasodilation. METHODS: The left anterior descending coronary artery of 14 open-chest dogs was perfused at constant pressure. Coronary blood flow (CBF) was measured electromagnetically and used to calculate myocardial oxygen consumption (MVO2). Responses were evaluated during intracoronary infusions (2 mL/ minute) of the ionic contrast medium, Hypaque-76, and the nonionic contrast medium, Isovue-370, and compared with those caused by hypertonic saline solutions with comparable osmolarities. Studies also were conducted using Isovist-300, which is a new nonionic and iso-osmolar contrast medium. RESULTS: Hypaque-76 and Isovue-370 caused initial peak increases in CBF (reflecting decreases in coronary vascular resistance), which waned rapidly to achieve more modest steady-state increases within 2 to 3 minutes. Both the peak and steady-state increases in CBF were greater during Hypaque-76 than during Isovue-370. The increases in CBF caused by the contrast medium were greater than those caused by the corresponding saline solution. Neither Hypaque-76 nor Isovue-370 changed MVO2-Isovist-300 had no effect on CBF or MVO2. CONCLUSIONS: The coronary vasodilation by contrast media is the result of a direct vasorelaxing effect rather than secondary to a metabolic mechanism. Hyperosmolarity can account only in part for contrast-induced coronary vasodilation. |
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Authors:
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G J Crystal; M R Salem |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Investigative radiology Volume: 31 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-01-17 Completed Date: 1997-01-17 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 556-62 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Illinois Masonic Medical Center, University of Illinois College of Medicine 60657, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media / pharmacology* Coronary Circulation / drug effects Coronary Vessels / drug effects* Diatrizoate / pharmacology Diatrizoate Meglumine / pharmacology Dogs Drug Combinations Female Iopamidol / pharmacology Male Myocardium / metabolism Osmolar Concentration Oxygen Consumption Saline Solution, Hypertonic / pharmacology Triiodobenzoic Acids / pharmacology Vasodilation / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL-47629/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Drug Combinations; 0/Saline Solution, Hypertonic; 0/Triiodobenzoic Acids; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 62883-00-5/Iopamidol; 79770-24-4/iotrolan; 8064-12-8/urovision |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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