| Investigations on the effectiveness of cefazedone in experimental E. coli pyelonephritis. | |
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MedLine Citation:
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PMID: 385009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The therapeutic effectiveness of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen), cephazolin, cephacetrile and cephalothin was compared in the test model of estradiol-induced E. coli pyelonephritis in the rat. Cefazedone and cephazolin were similar in effect. The relations between results of treatment and microbiological and pharmacokinetic characteristics of the cephalosporins tested are discussed. |
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Authors:
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K Sack; R Marre; H Freiesleben; W Henkel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 29 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1979 |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 414-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cephalosporins / metabolism, therapeutic use* Escherichia coli Infections / drug therapy* Female Kinetics Pyelonephritis / drug therapy*, etiology Rats |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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