Document Detail


Investigations on the effectiveness of cefazedone in experimental E. coli pyelonephritis.
MedLine Citation:
PMID:  385009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The therapeutic effectiveness of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen), cephazolin, cephacetrile and cephalothin was compared in the test model of estradiol-induced E. coli pyelonephritis in the rat. Cefazedone and cephazolin were similar in effect. The relations between results of treatment and microbiological and pharmacokinetic characteristics of the cephalosporins tested are discussed.
Authors:
K Sack; R Marre; H Freiesleben; W Henkel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  29     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1979  
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  414-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cephalosporins / metabolism,  therapeutic use*
Escherichia coli Infections / drug therapy*
Female
Kinetics
Pyelonephritis / drug therapy*,  etiology
Rats
Chemical
Reg. No./Substance:
0/Cephalosporins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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