Document Detail

Investigations on the effectiveness of cefazedone in experimental E. coli pyelonephritis.
MedLine Citation:
PMID:  385009     Owner:  NLM     Status:  MEDLINE    
The therapeutic effectiveness of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen), cephazolin, cephacetrile and cephalothin was compared in the test model of estradiol-induced E. coli pyelonephritis in the rat. Cefazedone and cephazolin were similar in effect. The relations between results of treatment and microbiological and pharmacokinetic characteristics of the cephalosporins tested are discussed.
K Sack; R Marre; H Freiesleben; W Henkel
Related Documents :
12208309 - Effect of season and artificial diet on amino acids and nucleic acids in gonads of gree...
1203259 - Elongation factor 2 as the target of the reaction product between sodium selenite and g...
17788289 - Mitosis and differentiation in roots treated with actinomycin.
822869 - Actions of aldosterone on rrna and na+ transport in the toad bladder.
12450849 - Aerobic metabolism of 4-hydroxybenzoic acid in archaea via an unusual pathway involving...
8679949 - Synthesis and characterization of the sweetness-suppressing polypeptide gurmarin and en...
7037139 - Effect of carbon source on growth rate and phospholipid composition of escherichia coli...
16232989 - H2 production from algal biomass by a mixed culture of rhodobium marinum a-501 and lact...
3026489 - Transformation of 15-hydroperoxyeicosapentaenoic acid to lipoxin a5 and b5, mono- and d...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  29     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1979  
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  414-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cephalosporins / metabolism,  therapeutic use*
Escherichia coli Infections / drug therapy*
Pyelonephritis / drug therapy*,  etiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bactericidal activity of cefazedone.
Next Document:  Antibiotic activity of cefazedone in experimental pyelonephritis.