Document Detail


Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study.
MedLine Citation:
PMID:  22088584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Botanicals represent an important and underexplored source of potential new therapies that may facilitate caloric restriction and thereby may produce long-term weight loss. In particular, one promising botanical that may reduce food intake and body weight by affecting neuroendocrine pathways related to satiety is hydroxycitric acid (HCA) derived from Garcinia cambogia Desr.
METHODS AND DESIGN: The objective of this article is to describe the protocol of a clinical trial designed to directly test the effects of Garcinia cambogia-derived HCA on food intake, satiety, weight loss and oxidative stress levels, and to serve as a model for similar trials. A total of 48 healthy, overweight or obese individuals (with a body mass index range of 25.0 to 39.9 kg/m(2)) between the ages of 50 to 70 will participate in this double-blind, placebo-controlled, crossover study designed to examine the effects of two doses of Garcinia cambogia-derived HCA on food intake, satiety, weight loss, and oxidative stress levels. Food intake represents the primary outcome measure and is calculated based on the total calories consumed at breakfast, lunch, and dinner meals during each test meal day. This study can be completed with far fewer subjects than a parallel design.
DISCUSSION: Of the numerous botanical compounds, the compound Garcinia cambogia-derived HCA is selected for testing in the present study because of its potential to safely reduce food intake, body weight, and oxidative stress levels. We will review potential mechanisms of action and safety parameters throughout this clinical trial.
TRIAL REGISTRATION: ClinicalTrials.gov (Identifier: NCT01238887).
Authors:
Stephen D Anton; Jonathan Shuster; Christiaan Leeuwenburgh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine     Volume:  9     ISSN:  1672-1977     ISO Abbreviation:  Zhong Xi Yi Jie He Xue Bao     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2012-03-15     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  101199657     Medline TA:  Zhong Xi Yi Jie He Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  1190-8     Citation Subset:  IM    
Affiliation:
Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida 32611, USA. santon@ufl.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01238887
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MeSH Terms
Descriptor/Qualifier:
Aged
Cross-Over Studies
Double-Blind Method
Drugs, Chinese Herbal / pharmacology*
Eating / drug effects
Humans
Middle Aged
Overweight
Oxidative Stress / drug effects*
Randomized Controlled Trials as Topic*
Research Design*
Satiation / drug effects*
Weight Loss / drug effects*
Grant Support
ID/Acronym/Agency:
1UL1RR029890/RR/NCRR NIH HHS; K23 AT004251/AT/NCCAM NIH HHS; U54RR025208/RR/NCRR NIH HHS; UL1 RR029890/RR/NCRR NIH HHS; UL1 TR000064/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal
Comments/Corrections

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