| Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. | |
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MedLine Citation:
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PMID: 18181738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We present 2 case reports in the United States and investigations of diphtheria-like illness caused by toxigenic Corynebacterium ulcerans. A fatal case occurred in a 75-year-old male Washington resident who was treated with clindamycin but did not receive equine diphtheria antitoxin. A second, nonfatal case occurred in a 66-year-old female Tennessee resident who received erythromycin and diphtheria antitoxin. METHODS: Both case patients and close human and animal contacts were investigated by their respective state health departments. RESULTS: C. ulcerans isolated from the patient who died was resistant to erythromycin and clindamycin. For both isolates, conventional polymerase chain reaction results were positive for A and B subunits of diphtheria toxin gene tox, and modified Elek tests confirmed toxin production. The source of infection remained undetermined for both cases. Neither patient was up-to-date with diphtheria toxoid vaccination. CONCLUSION: These case reports highlight the importance of early treatment with diphtheria antitoxin, the selection of effective antimicrobial agents, and prevention through up-to-date vaccination. |
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Authors:
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Tejpratap S P Tiwari; Anne Golaz; Diana T Yu; Kristen R Ehresmann; Timothy F Jones; Hal E Hill; Pamela K Cassiday; Lucia C Pawloski; John S Moran; Tanja Popovic; Melinda Wharton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 46 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-09 Completed Date: 2008-03-06 Revised Date: 2008-09-09 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 395-401 Citation Subset: IM |
Affiliation:
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Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. tit2@cdc.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Corynebacterium / isolation & purification* Corynebacterium Infections / drug therapy, epidemiology*, microbiology Diagnosis, Differential Diphtheria / epidemiology*, microbiology Diphtheria Antitoxin / therapeutic use Diphtheria Toxoid / therapeutic use Drug Resistance, Multiple, Bacterial Fatal Outcome Female Humans Male United States / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Diphtheria Antitoxin; 0/Diphtheria Toxoid |
| Comments/Corrections | |
Comment In:
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Clin Infect Dis. 2008 Jul 15;47(2):288; author reply 289
[PMID:
18564932
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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