Document Detail

Investigational drugs for neuroendocrine tumours.
MedLine Citation:
PMID:  19388877     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neuroendocrine tumours (NETs) are usually slow-growing neoplasms, which arise in the gastrointestinal tract, endocrine pancreas, lungs or thymus. The majority are malignant. The treatment of patients with metastatic disease consists of biotherapy with alpha-interferon and somatostatin analogues, various chemotherapy combinations or liver embolization. OBJECTIVE: To review and discuss new treatments for patients with metastatic NETs. METHOD: Review of the published literature during the last 5 years on treatment of patients with NETs. RESULTS/CONCLUSION: Several new drugs with various mechanisms of action including cytotoxic drugs, tyrosine kinase receptor inhibitors and antiangiogenic drugs as well as radiolabelled substances have been introduced during recent years. Many of these compounds have shown promising results in patients with NETs.
Dan Granberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  18     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  601-8     Citation Subset:  IM    
University Hospital, Institution of Medical Sciences, Department of Endocrine Oncology, Uppsala SE-75185, Sweden.
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MeSH Terms
Angiogenesis Inhibitors / chemistry,  therapeutic use
Antineoplastic Agents / chemistry,  therapeutic use*
Drugs, Investigational / chemistry,  therapeutic use*
Neuroendocrine Tumors / drug therapy*,  metabolism
Protein Kinase Inhibitors / chemistry,  therapeutic use
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antineoplastic Agents; 0/Drugs, Investigational; 0/Protein Kinase Inhibitors

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