Document Detail

Investigation of triclosan retention and dental plaque viability with a triclosan/PVM/MA copolymer mouthrinse in a Thai population.
MedLine Citation:
PMID:  19842422     Owner:  NLM     Status:  MEDLINE    
This investigation studied triclosan retention and plaque viability in a group of healthy human subjects from Bangkok, Thailand, 12 hours after using a mouthrinse containing a triclosan/PVM/MA copolymer system. The results show the retained triclosan in the dental plaque was with in or higher than the minimum inhibitory concentration (MIC range 0.27-6.25 microg/ml), indicating the triclosan in this product remains at an effective concentration in dental plaque. The 12-hour post-application evaluation demonstrated only 36.5% viability of oral bacteria in dental plaque after a one-time use of the mouthrinse. This study shows the benefits of using a mouthrinse containing a triclosan/PVM/MA copolymer system for providing 12 hours long-lasting anti-bacteria and dental plaque control.
Petcharat Kraivaphan; Cholticha Amornchat; Titikan Laothumthut; Terdphong Triratana
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  40     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2009-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  840-7     Citation Subset:  IM    
Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Anti-Infective Agents, Local / pharmacokinetics
Benzoates / pharmacokinetics*
Dental Plaque / drug therapy*,  microbiology
Double-Blind Method
Middle Aged
Mouthwashes / pharmacokinetics*
Polymethacrylic Acids / pharmacokinetics
Polyvinyls / pharmacokinetics
Sodium Dodecyl Sulfate / pharmacokinetics*
Triclosan / pharmacokinetics*
Young Adult
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Benzoates; 0/Mouthwashes; 0/Plax; 0/Polymethacrylic Acids; 0/Polyvinyls; 0/poly(1-vinylimidazole-co-methyl methacrylate) copolymer; 151-21-3/Sodium Dodecyl Sulfate; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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