Document Detail

Investigation of thyroxine monodeiodinase activity in the liver, kidney and brown adipose tissue of foetal and neonatal rabbit.
MedLine Citation:
PMID:  2084189     Owner:  NLM     Status:  MEDLINE    
The maturation of the 5'- and 5-monodeiodinase system in liver, kidney and brown adipose tissue of rabbits, during the foetal period (from 21 days of gestation to birth) and the neonatal period (from birth to 3 weeks of life) was studied. A sudden increase of 5'- and 5-monodeiodinase activity in liver and kidney 3 days before birth was observed, falling to a nadir at day 3 after birth. Foetal and neonatal serum T4, T3 and rT3 concentration were very low and rose progressively with age, reaching adult values at about day 21. In the foetal brown adipose tissue high 5'-monodeiodinase and low 5-monodeiodinase activity was found. The 5'-monodeiodinase decreased during the first days of life whereas the 5-monodeiodinase activity remained at a low stable level until day 3 when the activities of both enzymes increased. The increase of conversion rate of T4 to T3 and rT3 in liver and kidney well correlate with the triiodothyronines concentration in serum from day 3 after birth.
E Brzezińska-Slebodzińska; E Krysin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  13     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1991-05-14     Completed Date:  1991-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Department of Experimental Pathology of Animals, Polish Academy of Sciences, Poznań.
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MeSH Terms
Adipose Tissue, Brown / embryology,  enzymology*
Animals, Newborn / metabolism*
Fetus / metabolism*
Iodide Peroxidase / analysis*
Kidney / embryology,  enzymology*
Liver / embryology,  enzymology*
Thyroxine / blood
Triiodothyronine / blood
Triiodothyronine, Reverse / blood
Reg. No./Substance:
5817-39-0/Triiodothyronine, Reverse; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; EC Peroxidase

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