Document Detail

Investigation of surface properties of amino acids: polarity scale for amino acids as a means to predict surface exposed residues in films of proteins.
MedLine Citation:
PMID:  15276041     Owner:  NLM     Status:  MEDLINE    
It is of great interest and importance to study how different amino acid residues contribute to and affect the properties of proteins coated as films on solid surface. This work shows that the solid/liquid interfacial energy of surface localized amino acid films and their Gibbs energies of transfer at the air/solution interface have the potential to be used as a rapid and simple method for studying the surface properties of proteins. Based on these results, a new polarity scale for amino acids has been proposed. This scale is compared with existing hydropathy scales in a benchmark test using some proteins with solved 3D structure. The proteins were characterized in terms of surface-exposed residues with a computer program, Graphical Representation and Analysis of Surface Properties (GRASP). It was also shown that each amino acid contribution is relative to the total protein surface and the other residues on the surface.
R Maheshwari; Aruna Dhathathreyan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of colloid and interface science     Volume:  277     ISSN:  0021-9797     ISO Abbreviation:  J Colloid Interface Sci     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-07-27     Completed Date:  2005-05-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043125     Medline TA:  J Colloid Interface Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Chemical Laboratory, CLRI, Adyar, Chennai 600020, India.
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MeSH Terms
Amino Acids / chemistry*
Coated Materials, Biocompatible / chemistry
Membranes, Artificial
Proteins / chemistry*
Surface Properties
Reg. No./Substance:
0/Amino Acids; 0/Coated Materials, Biocompatible; 0/Membranes, Artificial; 0/Proteins

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