| Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs. | |
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MedLine Citation:
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PMID: 22235831 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of the study was to construct a screening programme for disseminated histiocytic sarcoma (DHS) in Bernese Mountain dogs using diagnostic imaging and blood analysis and evaluate blood borne biomarkers as early disease detection biomarkers. Healthy Bernese Mountain dogs were screened on four occasions in an attempt to detect early disease. Eleven blood borne biomarkers were examined for their worth as early tumour biomarkers. During 2.5 years, five dogs with early DHS were identified; four of these by diagnostic imaging. No dogs developed symptomatic DHS without being detected within 6 months of the screening programme. Only serum ferritin showed potential as a blood borne marker of the disease. Median survival times for the dogs with early DHS were 226 days. Screening programmes every 6 months for Bernese Mountain dogs over 4 years of age including diagnostic imaging and ferritin measurements may identify early DHS. |
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Authors:
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L N Nielsen; F McEvoy; L R Jessen; A T Kristensen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-11 |
Journal Detail:
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Title: Veterinary and comparative oncology Volume: - ISSN: 1476-5829 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101185242 Medline TA: Vet Comp Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Small Animal Clinical Studies, Faculty of Life Sciences, University of Copenhagen, Dyrlaegevej 16, 1870 Frederiksberg C, Denmark. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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