Document Detail


Investigation of rhythms of secretion and repeatability of plasma adrenocorticotropic hormone concentrations in healthy horses and horses with pituitary pars intermedia dysfunction.
MedLine Citation:
PMID:  23742059     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
REASONS FOR PERFORMING STUDY: There is little published information on whether measurement of plasma ACTH concentration at a single time point is a repeatable indicator of pituitary pars intermedia dysfunction (PPID). OBJECTIVES: To determine whether ultradian or circadian fluctuations in ACTH production influence plasma ACTH concentration in normal horses and horses with PPID. STUDY DESIGN: Prospective observational study. METHODS: Plasma ACTH concentration in 8 non-PPID horses and 8 horses with PPID was measured at 08.00, 11.00, 14.00 and 17.00 on 5 non-consecutive days within a 3 week period. In addition at 08.30 on one day, 6 samples were collected from each horse at precisely 5 min intervals over a period of 25 min. Descriptive and graphical analysis was performed and a linear mixed effects model was fitted to assess the effect of time of day on ACTH concentration in non-PPID and PPID horses. RESULTS: Evidence of ultradian fluctuation in ACTH production was not identified in either non-PPID or PPID horses. Evidence for circadian fluctuation was identified in non-PPID horses; plasma ACTH concentrations were highest at 08.00 am and decreased through the day. There was no evidence of circadian fluctuation in PPID horses. In non-PPID horses, the magnitude of circadian changes in ACTH concentration was smaller than variations in concentration that occurred at random. Intra-horse variability of ACTH concentration was greater in PPID horses than in non-PPID horses. CONCLUSIONS: Ultradian and circadian fluctuations in ACTH concentration are unlikely to influence clinical decision making; however, variations of potential clinical relevance do occur in individual horses, for reasons that remain to be determined, and increase in magnitude with progression of PPID. Results of the current study indicate that when an ACTH concentration between 19 and 40 pg/ml is measured, further testing should be considered to increase the accuracy of PPID diagnosis.
Authors:
D I Rendle; E Litchfield; J Heller; K J Hughes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-7
Journal Detail:
Title:  Equine veterinary journal     Volume:  -     ISSN:  2042-3306     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
School of Animal and Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, New South Wales, 2650, Australia.
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