Document Detail

Investigation of retroviral involvement in chronic fatigue syndrome.
MedLine Citation:
PMID:  8387909     Owner:  NLM     Status:  MEDLINE    
Within the last few years significant efforts have been made to identify objective reliable diagnostic markers from individuals with chronic fatigue syndrome (CFS). We report the absence of a previously described retroviral marker (HTLV-II gag) in a blinded study of CFS cases. Even with excellent reproducible sensitivities, this marker failed in repeated attempts to distinguish cases from controls. In addition, four other retroviruses (simian T cell leukaemia virus, human spumavirus, bovine leukaemia virus and simian retrovirus) were examined for their presence in these CFS cases and found to be absent. Our findings suggest that these agents, at least as markers, are non-distinguishing for CFS and that other factors may be confounding the resolution of an aetiology to this syndrome.
T M Folks; W Heneine; A Khan; T Woods; L Chapman; L Schonberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  173     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1993  
Date Detail:
Created Date:  1993-06-17     Completed Date:  1993-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  160-6; discussion 166-75     Citation Subset:  IM; X    
Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, GA 30333.
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MeSH Terms
Biological Markers / blood
Deltaretrovirus / isolation & purification
Fatigue Syndrome, Chronic / microbiology*
Polymerase Chain Reaction
Retroviridae / isolation & purification*
Reg. No./Substance:
0/Biological Markers

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