Document Detail

Investigation of the release behavior of diethylhexyl phthalate from the polyvinyl-chloride tubing for intravenous administration.
MedLine Citation:
PMID:  11163992     Owner:  NLM     Status:  MEDLINE    
The release behavior of diethylhexyl phthalate (DEHP) from a polyvinyl-chloride (PVC) tube, which is part of an intravenous administration set, was investigated with the coexistence of polysorbate 80 (Tween 80) in various solutions such as physiological saline (PS), distilled water for injection (DWI) and glucose solution (TZ). The cumulative amount of DEHP released after 5 h was in the following order; PS, DWI > 50% TZ. From a comparison of the amount of released DEHP and the critical micelle concentration (CMC) of various solutions, the lower the CMC of the solution, the higher the amount of DEHP released from the PVC tubing. When the concentration of Tween 80 was kept constant at 1 mg/ml, the cumulative amount of DEHP released with a flow rate 90 ml/h was higher than that at 60 ml/h. These results suggest that the release of DEHP from the PVC tubing is closely correlated with the interaction of Tween 80 and DEHP such as the formation of micelles, the collision of micelles against the surface of the PVC tubing and the diffusion properties of DEHP and or Tween 80 in the liquid medium.
T Hanawa; E Muramatsu; K Asakawa; M Suzuki; M Tanaka; K Kawano; T Seki; K Juni; S Nakajima
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  210     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-15     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  IM    
Department of Pharmacy, Yamanashi Medical University, Tamaho, Japan.
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MeSH Terms
Diethylhexyl Phthalate / chemistry*
Glucose / chemistry
Infusions, Intravenous
Polyvinyl Chloride / chemistry*
Surface Tension
Surface-Active Agents
Reg. No./Substance:
0/Micelles; 0/Polysorbates; 0/Surface-Active Agents; 117-81-7/Diethylhexyl Phthalate; 50-99-7/Glucose; 9002-86-2/Polyvinyl Chloride

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