| Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study. | |
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MedLine Citation:
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PMID: 22072085 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective. To clarify the clinical course of SSc in Japanese patients with early-onset disease. It is well known that ethnic variations exist in the clinical features and severity of SSc. However, neither the clinical course nor prognostic factors have been thoroughly investigated in the Japanese population.Methods. Ninety-three Japanese patients of early-onset SSc (disease duration: <3 years) with diffuse skin sclerosis and/or interstitial lung disease were registered in a multi-centre observational study. All patients had a physical examination with laboratory tests at their first visit and at each of the three subsequent years. Factors that could predict the severity of skin sclerosis and lung involvement were examined statistically by multiple regression analysis.Results. Two patients died from SSc-related myocardial involvement and four patients died from other complications during the 3-year study. Among various clinical data assessed, the initial modified Rodnan total skin thickness score (MRSS) and maximal oral aperture were associated positively and negatively with MRSS at Year 3, respectively. Additionally, initial ESR tended to be associated with final MRSS. Pulmonary vital capacity (VC) in the third year was significantly associated with initial %VC. Furthermore, patients with anti-topo I antibody tended to show reduced %VC at Year 3.Conclusions. Several possible prognostic factors for skin sclerosis and lung function were detected in Japanese patients with early SSc. Further longitudinal studies of larger populations will be needed to confirm these findings. |
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Authors:
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Minoru Hasegawa; Yoshihide Asano; Hirahito Endo; Manabu Fujimoto; Daisuke Goto; Hironobu Ihn; Katsumi Inoue; Osamu Ishikawa; Yasushi Kawaguchi; Masataka Kuwana; Yoshinao Muro; Fumihide Ogawa; Tetsuo Sasaki; Hiroki Takahashi; Sumiaki Tanaka; Kazuhiko Takehara; Shinichi Sato |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-9 |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: - ISSN: 1462-0332 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Department of Internal Medicine (Omori), Toho University School of Medicine, Tokyo, Department of Rheumatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Division of Rehabilitation Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Institute of Rheumatology, Tokyo Women's Medical University, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Department of Dermatology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Department of Dermatology, Atami Hospital, International University of Health and Welfare, Atami, First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo and Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan. |
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