| Investigation of the possibility of using ischemia-modified albumin in testicular torsion: an experimental study. | |
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MedLine Citation:
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PMID: 20452583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the serum ischemia-modified albumin levels with use of an experimental testicular torsion (TT) model. DESIGN: Randomized, controlled experimental study. SETTING: University hospital. ANIMAL(S): Thirty mature male Wistar rats. INTERVENTION(S): Rats were divided into five groups: a sham operation group, 2- and 4-hour control (groups I and III, respectively), and 2- and 4-hour torsion groups (groups II and IV, respectively). Ischemia-modified albumin, tissue and blood malondialdehyde (MDA), tissue and blood myeloperoxidase (MPO) activity levels, and histopathologic damage scores then were compared. MAIN OUTCOME MEASURE(S): Ischemia-modified albumin, tissue and blood MDA, tissue and blood MPO activity levels, and histopathologic damage scores. RESULT(S): There was a significantly higher level of histopathologic damage in the 4-hour torsion group, and the serum ischemia-modified albumin levels in this group were significantly higher than those of the other groups. There was no difference between the groups in terms of blood and tissue MDA and MPO levels. There was no significant correlation between ischemia-modified albumin levels and blood and tissue MDA and MPO levels. The only significant correlation between histopathologic score and biochemical markers was that with blood and tissue MPO. CONCLUSION(S): The results from this pioneering study determined a high level of ischemia-modified albumin in TT, indicating a potential value for TT diagnosis. The value of ischemia-modified albumin levels in TT should be investigated also with respect to prognosis. |
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Authors:
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Omer Kutlu; Ahmet Mentese; Suha Turkmen; Suleyman Turedi; Abdulkadir Gunduz; Esin Yulug; Ahmet Alver; Suleyman Caner Karahan |
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Publication Detail:
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Type: Journal Article Date: 2010-05-08 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-07 Completed Date: 2011-05-12 Revised Date: 2011-08-12 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1333-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Disease Models, Animal* Ischemia / blood*, diagnosis Male Rats Rats, Wistar Serum Albumin / analysis, metabolism* Spermatic Cord Torsion / blood*, diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Serum Albumin |
| Comments/Corrections | |
Comment In:
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Fertil Steril. 2011 Jun 30;95(8):e81; author reply e82-3
[PMID:
21605861
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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