Document Detail


Investigation of the pharmacokinetics and analgesic effects of an intramuscular injection of sustained-release sufentanil for postoperative pain: an open study.
MedLine Citation:
PMID:  7880508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVES: To investigate the pharmacokinetics after an intramuscular (IM) injection of sufentanil in thin vegetable oil in postsurgical patients and to determine whether sustained-release IM sufentanil can provide safe and sufficient analgesia of long duration in these patients. DESIGN: Open study. SETTING: University hospital. PATIENTS: 10 ASA physical status I and II patients aged 18 to 65 years who were scheduled for elective surgery. INTERVENTIONS: All patients were premedicated with lorazepam and anesthetized with a general anesthetic technique containing nitrous oxide, fentanyl, and isoflurane. As soon as significant pain [visual analog scale score of 5 or greater (range, 0 = no pain to 10 = worst pain imaginable)] occurred during the early postoperative period, the patient received an IM injection of sustained-release sufentanil. MEASUREMENTS AND MAIN RESULTS: During the first 48 hours following surgery, blood samples were taken for determination of plasma sufentanil concentrations. Blood pressure, heart rate, respiratory rate, pain scores, and sedation scores were documented at the same time. The IM administration of sufentanil in thin vegetable oil provided sufficient pain relief, although the onset of analgesia was rather slow (+/- 1 hour). The analgesic effect was still apparent 48 hours later. Plasma concentration of sufentanil at the different time points varied from 0.021 to 0.142 ng/ml, with a mean maximal peak concentration of 0.103 ng/ml. The plasma concentration 48 hours after injection varied from 0.026 to 0.074 ng/ml. CONCLUSIONS: Although an IM injection of sufentanil in thin vegetable oil is effective for postoperative pain relief, it is associated with wide interindividual variability in plasma concentration of sufentanil and long duration of action.
Authors:
G Bergmans; B Vanacker; H Van Aken; H Noorduin; A Van Peer; J Gryseels; B Verhamme
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  6     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-04-07     Completed Date:  1995-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  462-8     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Katholieke Universiteit Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anesthesia, General
Blood Pressure / drug effects
Delayed-Action Preparations
Female
Heart Rate / drug effects
Humans
Injections, Intramuscular
Lorazepam / administration & dosage
Male
Middle Aged
Pain, Postoperative / drug therapy*
Plant Oils
Preanesthetic Medication
Respiration / drug effects
Sufentanil / administration & dosage,  blood,  pharmacokinetics*,  pharmacology*
Surgical Procedures, Elective
Time Factors
Vehicles
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Plant Oils; 0/Vehicles; 56030-54-7/Sufentanil; 846-49-1/Lorazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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