Document Detail

Investigation of optimal drug in moderate bronchial asthma
MedLine Citation:
PMID:  17671411     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Many drugs and the combinations of drugs are recommended for each treatment step in bronchial asthma. However, there are few issues examined about the optimal drug and combination of drugs in a long term prognosis. In this study, we investigated the optimal drugs and combinations of drugs from a point of view of prognosis. METHODS: One hundred and ninety four patients who visited our hospital for treatment from November, 2003 to October, 2004 and were managed according to GINA guideline were surveyed retrospectively. We compared the rate of step up and the frequency of urgent visit and urgent hospitalization in one year between drug groups in each treatment step. RESULTS: The rate of step up was significantly higher in leukotriene receptor antagonist (LTRA) group than in inhalation corticosteroid (ICS) group and theophylline group in Step 2. The frequency of urgent visit and urgent hospitalization was significantly higher in ICS+LTRA group than in ICS+theophylline group and ICS+long-acting beta 2-agonist (LABA) group in Step 3. CONCLUSION: There is a possibility that the prognosis becomes bad when we use LTRA in the practical treatment according to GINA guideline.
Akihisa Kataoka; Naoki Nishimura; Noboru Uchiyama; Hiroshi Ono; Jun Kishi; Naohiko Chonabayashi
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Arerugī = [Allergy]     Volume:  56     ISSN:  0021-4884     ISO Abbreviation:  Arerugi     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-09-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0241212     Medline TA:  Arerugi     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  685-90     Citation Subset:  IM    
Department of Respiratory Medicine, St. Luke's International Hospital.
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MeSH Terms
Administration, Inhalation
Adrenal Cortex Hormones / administration & dosage*
Adrenergic beta-Agonists / administration & dosage*
Asthma / drug therapy*
Drug Administration Schedule
Drug Therapy, Combination
Leukotriene Antagonists / administration & dosage*
Middle Aged
Practice Guidelines as Topic
Retrospective Studies
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Adrenergic beta-Agonists; 0/Leukotriene Antagonists

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