Document Detail

Investigation of new co-factors in 49 patients with pyoderma gangrenosum.
MedLine Citation:
PMID:  21762379     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pyoderma gangrenosum is a rare, destructive, ulcerative neutrophilic dermatosis of unknown origin that has been investigated insufficiently in clinical studies. According to current textbooks, it is often associated with chronic inflammatory bowel diseases or other autoimmune disorders.
PATIENTS AND METHODS: We retrospectively analyzed data from 49 patients with pyoderma gangrenosum.
RESULTS: Our results showed that although only 6.1 % of patients had chronic inflammatory bowel disease, 22.4 % patients had a malignancy, 18.4 % had chronic renal insufficiency, and 42.8 % had anemia. A potentially relevant aspect that has received little attention is an association with endocrine diseases in 38.8 % of patients. 28.6 % of patients had diabetes. Given that 32.6 % of patients were obese, a potential association with metabolic syndrome may be considered as a possible new risk factor for pyoderma gangrenosum.
CONCLUSIONS: The clinical data from the present study are insufficient for drawing any firm conclusions. We did, however, observe an association between pyoderma gangrenosum and certain as yet unreported co-factors, in particular metabolic syndrome. This should be considered in further studies.
Philipp Al Ghazal; Andreas Körber; Joachim Klode; Joachim Dissemond
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Publication Detail:
Type:  Journal Article     Date:  2011-07-15
Journal Detail:
Title:  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG     Volume:  10     ISSN:  1610-0387     ISO Abbreviation:  J Dtsch Dermatol Ges     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-22     Completed Date:  2012-07-23     Revised Date:  2012-09-25    
Medline Journal Info:
Nlm Unique ID:  101164708     Medline TA:  J Dtsch Dermatol Ges     Country:  Germany    
Other Details:
Languages:  eng; ger     Pagination:  251-7     Citation Subset:  IM    
Copyright Information:
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.
Clinic and Polyclinic for Dermatology, Venereology, and Allergology, Essen University Hospital, Hufelandstrasse 55, Essen, Germany.
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MeSH Terms
Aged, 80 and over
Anemia / epidemiology*
Chronic Disease
Endocrine System Diseases / epidemiology*
Germany / epidemiology
Inflammatory Bowel Diseases / epidemiology*
Kidney Failure, Chronic / epidemiology*
Middle Aged
Neoplasms / epidemiology*
Obesity / epidemiology*
Pyoderma Gangrenosum / epidemiology*
Risk Assessment
Risk Factors
Comment In:
J Dtsch Dermatol Ges. 2012 Aug;10(8):590-1; author reply 591-2   [PMID:  22830661 ]

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