Document Detail

Investigation of iodine deficient state and iodine supplementation in patients with severe motor and intellectual disabilities on long-term total enteral nutrition.
MedLine Citation:
PMID:  22673532     Owner:  NLM     Status:  MEDLINE    
Iodine concentrations of enteral nutrition (EN) formulae available in Japan are very low and long-term total EN (TEN) might result in hypothyroidism due to iodine deficiency (HID). Our aim of this study was to determine the degree of iodine deficiency (ID) and need for iodine supplementation (IS) in patients with severe motor and intellectual disabilities (SMID) on long-term TEN. Thyroid function including urinary iodine concentration (UIC) was monitored, and powdered kelp was provided as a source of iodine supplement. Thirty-five SMID on TEN participated in our study. UIC less than 100 μg /L, representing ID, were detected in 97 % of them. Their TSH ranged from 0.5 to 90 μIU/mL. IS using powdered kelp raised their UIC to the normal range. Thyroid function also recovered in the five hypothyroidism cases, which were diagnosed as HID, was also detected. In Japan, there must be many cases with ID associated with long term TEN. We also discuss the regulation of thyroid function in the iodine deficient state.
Takako Takeuchi; Hotaka Kamasaki; Yuko Yoto; Takashi Honjo; Satoshi Tsugawa; Tomoyuki Hotsubo; Hiroyuki Tsutsumi
Publication Detail:
Type:  Journal Article     Date:  2012-05-25
Journal Detail:
Title:  Endocrine journal     Volume:  59     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-01-30     Revised Date:  2014-11-10    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  697-703     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Dietary Supplements
Enteral Nutrition / adverse effects*
Hypothyroidism / diet therapy,  etiology*
Intellectual Disability / complications
Iodine / deficiency*,  therapeutic use,  urine
Movement Disorders / complications
Nutritional Status
Thyroid Gland / physiology
Reg. No./Substance:

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