| Investigation into the erosion mechanism of salicylate-based poly(anhydride-esters). | |
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MedLine Citation:
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PMID: 16315189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salicylate-based poly(anhydride-esters), collectively referred to as PolyAspirin, hydrolytically degrade into salicylic acid, a nonsteroidal anti-inflammatory drug (NSAID). The variations of the poly(anhydride-ester) investigated in this article are linked by adipic acid, suberic acid, or sebacic acid. To elucidate the erosion mechanism of these polymers, water uptake, mass loss, contact angle, and changes in device thickness were monitored as a function of in vitro degradation time. The polymers examined here appeared to primarily undergo surface erosion. The adipate homopolymer absorbed the most water and therefore swelled more than the other versions of the poly(anhydride-ester). Additionally, the adipate homopolymer eroded most quickly. Increasing the length of the linker moiety decreased the driving force for hydrolysis, which prolonged the lifetime of the polymer sample. |
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Authors:
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Kenya Whitaker-Brothers; Kathryn Uhrich |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 76 ISSN: 1549-3296 ISO Abbreviation: - Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-05-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 470-9 Citation Subset: IM |
Copyright Information:
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(c) 2005 Wiley Periodicals, Inc. |
Affiliation:
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Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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chemistry* Biocompatible Materials / chemistry* Materials Testing / methods Polyanhydrides / chemistry* Polyesters / chemistry* Salicylates / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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DE 13207/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Biocompatible Materials; 0/Polyanhydrides; 0/Polyesters; 0/Salicylates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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