Document Detail

Investigation into a cluster of infant deaths following immunization: evidence for methanol intoxication.
MedLine Citation:
PMID:  12297405     Owner:  NLM     Status:  MEDLINE    
A cluster of infant deaths due to severe metabolic acidosis following immunization was reported in a prosperous farming village in Egypt. Fears that more deaths might occur, and of a deleterious effect on national immunization programs prompted an urgent investigation by national and international partners. The deaths, and other previously unrecognized illness following immunization, were associated with excessive topical application of methanol. Methanol was employed as an anti-pyretic and anti-inflammatory agent following injections. Fear of adverse reactions to vaccine had encouraged increasing use of methanol for these purposes. Local physicians and nurses were unaware of the toxicity of methanol and did not consider it in the differential diagnosis, and thus did not offer appropriate life-saving therapy. The interaction of traditional practices and modern medical interventions can have clinically important consequences, and should be considered when programs are introduced and as they are monitored.
A Darwish; C E Roth; P Duclos; S A Ohn; A Nassar; F Mahoney; R Vogt; R R Arthur
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Vaccine     Volume:  20     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-25     Completed Date:  2003-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3585-9     Citation Subset:  IM    
Expanded Program on Immunization, Ministry of Health and Population, Cairo, Egypt.
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MeSH Terms
Cohort Studies
Fatal Outcome
Methanol / poisoning*
Vaccination / adverse effects*
Reg. No./Substance:

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