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Investigation into bacteremia and spontaneous bacterial peritonitis in patients with liver cirrhosis in Japan.
MedLine Citation:
PMID:  22706739     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background/aims: Liver cirrhosis patients tend to develop bacteremia, but relatively little has been reported about the situation in Japan. Therefore, we investigated the microorganisms involved and the outcome among liver cirrhosis patients with bacteremi- a, including spontaneous bacterial peritonitis. Methods: The subjects were 236 patients who underwent a total of 377 blood cultu- res and 30 patients diagnosed with spontaneous bacterial peritonitis, among 6,096 inpatients with liver cirrhosis admitted to seve- ral hospitals during the period 1991-2009. Results: The rate of positive blood culture was 37.1% (140/377), and the isolated mic- roorganisms were predominantly Gram-negative bacteria. In patients with confirmed bacteremia, the Child-Pugh score and serum blood urea nitrogen and creatinine levels were significantly higher than in non-bacteremia cases. Moreover, short-term mortality (within 1 month) was 48.2% (53/110), being significantly higher than that among non-bacteremia cases (18.8%; 22/117). Among spontaneous bacterial peritonitis cases, mortality within one month was 33.3% (10/30). Again, the Child-Pugh score and serum blo- od urea nitrogen and creatinine levels were significantly higher among the fatalities than among survivors. Conclusions: These re- sults indicate that severity of liver dysfunction and severity of renal dysfunction are both important determinants of short-term mor- tality among liver cirrhosis patients with bacteremia and spontaneous bacterial peritonitis in Japan.
Authors:
Toru Shizuma; Naoto Fukuyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology     Volume:  23     ISSN:  1300-4948     ISO Abbreviation:  Turk J Gastroenterol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-06-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9515841     Medline TA:  Turk J Gastroenterol     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine Tokai University, 143, Shimokasuya Isehara, Kanagawa 259-1193 Japan. shizuma@is.icc.u-tokai.ac.jp.
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