| Investigation of the inclusion complex of β-cyclodextrin with mycophenolate mofetil. | |
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MedLine Citation:
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PMID: 22306450 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The acid-base equilibrium of mycophenolate mofetil is studied in the absence and presence of β-cyclodextrin (β-CD). The conditional acidity constants are obtained by rank annihilation factor analysis (RAFA) as a function of β-CD concentrations. Also the stability constants for inclusion complexes of β-CD with both acidic and basic forms are calculated. The conditional acidity constant decreases by increasing β-CD concentration. The calculated stability constants show that the acidic form of mycophenolate mofetil forms more stable inclusion complex (552±7M(-1)) than its basic anionic form (158±2M(-1)). |
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Authors:
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Lida Khalafi; Mohammad Rafiee; Fatemeh Mahdiun; Sajjad Sedaghat |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
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Title: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Volume: 90C ISSN: 1873-3557 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602533 Medline TA: Spectrochim Acta A Mol Biomol Spectrosc Country: - |
Other Details:
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Languages: ENG Pagination: 45-49 Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Chemistry, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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