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An Investigation on in vitro and in vivo Antimicrobial Properties of the Antidepressant: Amitriptyline Hydrochloride.
MedLine Citation:
PMID:  24031539     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The antidepressant drug amitriptyline hydrochloride was obtained in a dry powder form and was screened against 253 strains of bacteria which included 72 Gram positive and 181 Gram negative bacteria and against 5 fungal strains. The minimum inhibitory concentration (MIC) was determined by inoculating a loopful of an overnight peptone water culture of the organism on nutrient agar plates containing increasing concentrations of amitriptyline hydrochloride (0, 10 μg/mL, 25 μg/mL, 50 μg/mL, 100 μg/mL, 200 μg/mL). Amitriptyline hydrochloride exhibited significant action against both Gram positive and Gram negative bacteria at 25-200 μg/mL. In the in vivo studies it was seen that amitriptyline hydrochloride at a concentration of 25 μg/g and 30 μg/g body weight of mouse offered significant protection to Swiss strain of white mice when challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella typhimurium NCTC 74. The in vivo data were highly significant (p<0.001) according to the chi-square test.
Anurup Mandal; Chandrima Sinha; Aditya Kumar Jena; Soma Ghosh; Amalesh Samanta
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Publication Detail:
Type:  Journal Article     Date:  2010-09-01
Journal Detail:
Title:  Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]     Volume:  41     ISSN:  1517-8382     ISO Abbreviation:  Braz. J. Microbiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2013-09-13     Completed Date:  2013-09-13     Revised Date:  2013-09-18    
Medline Journal Info:
Nlm Unique ID:  101095924     Medline TA:  Braz J Microbiol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  635-45     Citation Subset:  -    
Division of Microbiology, Department of Pharmaceutical Technology , Jadavpur University, Kolkata (Calcutta)-700032 , India .
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