Document Detail

Investigation of the felodipine glassy state by atomic force microscopy.
MedLine Citation:
PMID:  11337158     Owner:  NLM     Status:  MEDLINE    
The glassy state of felodipine was prepared by melting crystals of felodipine on a clean glass slide and cooling to room temperature. It has been confirmed that glassy felodipine is a metastable state, and undergoes transformation to the more stable crystalline form. Crystallization occurred slowly and spontaneously at room temperature, below the glassy state transition temperature (Tg). The contact mode of atomic force microscopy was used for topographical imaging of the glassy and crystalline states of felodipine. When the glassy felodipine region next to the recrystallized zone was exposed to controlled mechanical stress through the tip, rapid additional crystallization was observed. This crystallization process can be induced and imaged in real time by atomic force microscopy.
A Trojak; K Kocevar; I Musevic; S Srcic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  218     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-51     Citation Subset:  IM    
University of Ljubljana, Faculty of Pharmacy, Askerceva 7, SI-1000, Ljubljana, Slovenia.
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MeSH Terms
Calcium Channel Blockers / chemistry*
Felodipine / chemistry*
Microscopy, Atomic Force*
Reg. No./Substance:
0/Calcium Channel Blockers; 72509-76-3/Felodipine

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