Document Detail

Investigation of the effects of paralysis by pancuronium on heart rate variability, blood pressure and fluid balance.
MedLine Citation:
PMID:  2603705     Owner:  NLM     Status:  MEDLINE    
The effects of pancuronium bromide on the cardiovascular system and fluid balance in preterm ventilated neonates was investigated. Infants were selectively paralysed if actively expiring. Their results were compared to a control group of similar gestational age, ventilated during the same study period, but who received no paralysing agent. There was no significant difference in the blood pressure of the two groups. Treatment with pancuronium was not associated with differences in blood pressure variability. All paralysed infants showed a significant reduction in heart rate variability which persisted during treatment. This was not present in the control infants. Paralysed infants, despite fluid restriction, had evidence of fluid retention, being significantly heavier than the control babies from day 3 onwards and above their birthweight by day 7. No paralysed or control infant developed a pneumothorax or renal failure. We conclude that selective treatment with pancuronium is without adverse effects on blood pressure but strict attention to fluid balance is essential.
A Greenough; H R Gamsu; F Greenall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  78     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-01-30     Completed Date:  1990-01-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  829-34     Citation Subset:  IM    
Department of Child Health, King's College Hospital, London, England.
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MeSH Terms
Blood Pressure / drug effects*
Heart Rate / drug effects*
Infant, Newborn
Infant, Premature*
Muscle Relaxation / drug effects
Pancuronium / administration & dosage*,  adverse effects
Respiratory Muscles / drug effects
Water-Electrolyte Balance / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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