Document Detail

Investigation of the effectiveness of Ascopyrone P as a food preservative.
MedLine Citation:
PMID:  15163588     Owner:  NLM     Status:  MEDLINE    
Ascopyrone P (APP), a novel antibacterial from fungi, was evaluated as a food preservative. Efficacy was generally assessed by comparing the time taken for test strains to grow to 10(6) CFU/g in food +/- APP. In chilled chicken soup, 2000 mg kg-1 APP prevented Bacillus cereus, Listeria monocytogenes, Pseudomonas fluorescens, Salmonella and Escherichia coli reaching this threshold for >60 days. Good activity was also observed at 500-1000 mg kg-1 but not against L. monocytogenes. No activity was observed against Saccharomyces cerevisiae. Activity was reduced at 20 degrees C, although 2000 mg kg-1 was still effective against B. cereus and P. fluorescens. APP was less effective in chilled cooked meat systems and ineffective in raw meat. In a cooked meat system at 8 degrees C, bacteriostatic effect was generally observed at 2000 mg kg-1 against Salmonella typhimurium, E. coli and P. fluorescens but not against L. monocytogenes or Lactobacillus sake. Activity against Gram-negative enteric bacteria was enhanced by low temperature. In milk, 2000 mg l-1 was effective against P. fluorescens at chilled but not ambient temperature. APP was ineffective against yeasts and the mould Byssochlamys in apple juice. A minimum of 2000 mg kg-1 APP would appear to be necessary for antibacterial efficacy in food, although low-temperature storage may help. Observed variations in sensitivity may be related to APP stability, which decreases >pH 5.5. Toxicology testing is needed before consideration of APP for food use.
Linda V Thomas; Richard E Ingram; Shukun Yu; Joss Delves-Broughton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of food microbiology     Volume:  93     ISSN:  0168-1605     ISO Abbreviation:  Int. J. Food Microbiol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-27     Completed Date:  2004-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412849     Medline TA:  Int J Food Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  319-23     Citation Subset:  IM    
Danisco, Innovation Department, 15 North Street, Beaminster, Dorset, DT8 3DZ, UK.
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MeSH Terms
Anti-Bacterial Agents / metabolism,  pharmacology*,  toxicity
Ascomycota / growth & development,  metabolism*
Colony Count, Microbial
Consumer Product Safety
Dose-Response Relationship, Drug
Food Microbiology*
Food Preservation / methods*
Food Preservatives / metabolism,  pharmacology*,  toxicity
Hydrogen-Ion Concentration
Sensitivity and Specificity
Species Specificity
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Food Preservatives

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