Document Detail


Investigation of a dual-particle liquid-solid circulating fluidized bed bioreactor for extractive fermentation of lactic acid.
MedLine Citation:
PMID:  19194893     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A dual-particle liquid-solid circulating fluidized bed (DP-LSCFB) bioreactor has been constructed and investigated for the simultaneous production and extraction of lactic acid using immobilized Lactobacillus bulgaricus and ion-exchange resins. The apparatus consisted of a downer fluidized bed, 13 cm I.D. and 4.75 m tall, and a riser fluidized bed, 3.8 cm I.D. and 5.15 m in height. The lactic acid production and removal was carried out in the downer, while the riser was used for the recovery of lactic acid. A continuously recirculating bed of ion-exchange resin was used for adsorption of the produced acid as well as for maintaining optimum pH for bioconversion, thus eliminating the need for costly and complex chemical control approach used in conventional techniques. Studies using lactic acid aqueous solution as feed and sodium hydroxide solution as regeneration stream showed 93% lactic acid removal from the downer and 46% recovery in the riser under the conditions investigated. Such results prove the functionality of using the newly developed bioreactor design for the continuous production and recovery of products of biotechnological significance.
Authors:
Manoj Patel; Amarjeet S Bassi; Jesse J-X Zhu; Hassan Gomaa
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biotechnology progress     Volume:  24     ISSN:  1520-6033     ISO Abbreviation:  Biotechnol. Prog.     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2009-02-05     Completed Date:  2009-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506292     Medline TA:  Biotechnol Prog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  821-31     Citation Subset:  IM    
Affiliation:
Dept. of Chemical and Biochemical Engineering, University of Western Ontario, London, ON, Canada N6A 5B9.
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MeSH Terms
Descriptor/Qualifier:
Biocatalysis
Bioreactors / microbiology*
Cells, Immobilized / chemistry,  metabolism
Culture Techniques / methods*
Fermentation*
Industrial Microbiology / instrumentation,  methods*
Ion Exchange Resins / chemistry
Lactic Acid / chemistry,  isolation & purification,  metabolism*
Lactobacillus / chemistry,  metabolism*
Chemical
Reg. No./Substance:
0/Ion Exchange Resins; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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