Document Detail

Investigation of the distribution and excretion of okadaic acid in mice using immunostaining method.
MedLine Citation:
PMID:  11689237     Owner:  NLM     Status:  MEDLINE    
This paper describes the distribution and excretion of okadaic acid (OA) administered orally to mice and examined by immunostaining method. Five min after administration, OA was systemically distributed, being detected in the lung, liver, heart, kidney, and small and large intestine. The swollen small intestinal villi contained OA, causing the separation of epithelial cells from villi and erosion, which developed within 1h. Bleeding and edema in the lung were also found, and the distribution of OA coincided with these injuries. Although a considerable amount of OA was accumulated in the liver, no symptoms, such as bleeding, were observed. The detection of OA continued for 2 weeks in the liver and blood vessels. Excretion from kidney, cecum and large intestine began even after 5 min of the administration, and the excretion from intestine continued for 4 weeks.
Emiko Ito; Takeshi Yasumoto; Akira Takai; Susumu Imanishi; Kenichi Harada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  40     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2002-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8673, Japan.
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MeSH Terms
Administration, Oral
Carcinogens / administration & dosage,  pharmacokinetics*
Injections, Spinal
Intestines / metabolism,  pathology
Kidney / metabolism,  pathology
Liver / metabolism,  pathology
Marine Toxins / administration & dosage,  pharmacokinetics*
Mice, Inbred ICR
Okadaic Acid / administration & dosage,  pharmacokinetics*
Organ Size
Peptides, Cyclic / administration & dosage,  pharmacokinetics
Stomach / metabolism,  pathology
Tissue Distribution
Reg. No./Substance:
0/Carcinogens; 0/Marine Toxins; 0/Microcystins; 0/Peptides, Cyclic; 101043-37-2/cyanoginosin LR; 78111-17-8/Okadaic Acid

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