| Investigation of cystatin C and cystatin C based estimated glomerular filtration rate in pregnant patients with heart failure. | |
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MedLine Citation:
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PMID: 22706257 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Background: Impaired cardiac function leads to impaired renal function. We assessed renal function in pregnant patients with heart failure. Methods: This was a retrospective study. From 1999 to 2010, 42 pregnant patients with heart failure were classified into the single-pregnancy group and the twin or multifetation group. Clinical manifestations were assessed. Serum concentrations of creatinine and cystatin C were assessed. Estimated glomerular filtration rate (eGFR) based on serum concentrations of creatinine or cystatin C was completed. Results: There were 29 single pregnancies, 12 twin pregnancies, and one multifetation. Ten patients in the twin pregnancy or multifetation group had in-vitro fertilization. The concentration of creatinine was 84.6±33.8 μmol/L and the creatinine-based eGFR was 87.2±34.9 mL/min per 1.73 m2. The percentage of patients with a creatinine based eGFR<60 mL/min per 1.73 m2was 23.8%. The concentration of cystatin C was 1.5±0.7 mg/L and the cystatin C-based eGFR was 65.2±45.8 mL/min per 1.73 m2. The percentage of patients with a cystatin C-based eGFR<60 mL/min per 1.73 m2was 52.4%. Conclusions: Serum concentrations of cystatin C and cystatin C-based eGFR are important indicators of renal impairment in pregnant patients with heart failure. |
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Authors:
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Mengyan Xu; Zhidong Guo; Qiqi Wang; Jianmei Jin; Tao Wu; Yuangang Qiu |
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Publication Detail:
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Type: Journal Article Date: 2012-01-25 |
Journal Detail:
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Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 50 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
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Languages: eng Pagination: 1125-8 Citation Subset: IM |
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