Document Detail

Investigation of cutaneous microvascular activity and flare response in patients with fibromyalgia syndrome.
MedLine Citation:
PMID:  11600737     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess microvascular activity in the skin of patients with fibromyalgia syndrome (FMS) as compared with normal controls. METHODS: Fifteen patients, who fulfilled the American College of Rheumatology criteria for FMS, and 15 age- and sex-matched healthy controls, were studied. The microvascular activity of the skin overlying the trapezius muscle was quantified using iontophoresis of acetylcholine as an endothelial-dependent vasodilator and sodium nitroprusside as an endothelial-independent vasodilator. We also studied the flare response by iontophoresing acetylcholine continuously for 10 min to stimulate a ring of nociceptor c-fibre endings in the skin. RESULTS: There was no significant difference in cutaneous vascular responses to short-duration iontophoresis of acetylcholine and sodium nitroprusside at the three different doses used. The area under the curve (AUC) (mean+/-s.e.m.) for acetylcholine baseline, 20, 40, and 80 s were 6+/-0.7, 23+/-6, 45+/-7 and 66+/-10 AU for patients and 11+/-4, 24+/-3, 49+/-7 and 62+/-12 AU for controls, respectively (P=0.2, 0.9, 0.7, 0.8, respectively). The corresponding figures for sodium nitroprusside were 5+/-1, 18+/-7, 51+/-14 and 68+/-14 AU for patients and 8+/-3, 13+/-2, 39+/-5 and 61+/-9 AU for controls, respectively (P=0.2, 0.5, 0.4, 0.7, respectively). There was also no significant difference in the flare response in patients with FMS as compared with control subjects (119+/-15 and 131+/-13 AU, respectively; P=0.57). CONCLUSION: There are no significant differences in cutaneous microvascular reactivity between patients with FMS and control subjects.
A W Al-Allaf; F Khan; J Moreland; J J Belch; T Pullar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  40     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-15     Completed Date:  2001-12-04     Revised Date:  2007-09-06    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1097-101     Citation Subset:  AIM; IM    
Rheumatic Disease Unit, University Department of Medicine, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK.
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MeSH Terms
Acetylcholine / diagnostic use
Fibromyalgia / physiopathology*
Microcirculation / physiology
Middle Aged
Nerve Fibers / physiology
Nitroprusside / diagnostic use
Nociceptors / drug effects,  physiology
Regional Blood Flow / drug effects,  physiology
Skin / blood supply*,  innervation
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine

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