| Investigation of cutaneous microvascular activity and flare response in patients with fibromyalgia syndrome. | |
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MedLine Citation:
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PMID: 11600737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess microvascular activity in the skin of patients with fibromyalgia syndrome (FMS) as compared with normal controls. METHODS: Fifteen patients, who fulfilled the American College of Rheumatology criteria for FMS, and 15 age- and sex-matched healthy controls, were studied. The microvascular activity of the skin overlying the trapezius muscle was quantified using iontophoresis of acetylcholine as an endothelial-dependent vasodilator and sodium nitroprusside as an endothelial-independent vasodilator. We also studied the flare response by iontophoresing acetylcholine continuously for 10 min to stimulate a ring of nociceptor c-fibre endings in the skin. RESULTS: There was no significant difference in cutaneous vascular responses to short-duration iontophoresis of acetylcholine and sodium nitroprusside at the three different doses used. The area under the curve (AUC) (mean+/-s.e.m.) for acetylcholine baseline, 20, 40, and 80 s were 6+/-0.7, 23+/-6, 45+/-7 and 66+/-10 AU for patients and 11+/-4, 24+/-3, 49+/-7 and 62+/-12 AU for controls, respectively (P=0.2, 0.9, 0.7, 0.8, respectively). The corresponding figures for sodium nitroprusside were 5+/-1, 18+/-7, 51+/-14 and 68+/-14 AU for patients and 8+/-3, 13+/-2, 39+/-5 and 61+/-9 AU for controls, respectively (P=0.2, 0.5, 0.4, 0.7, respectively). There was also no significant difference in the flare response in patients with FMS as compared with control subjects (119+/-15 and 131+/-13 AU, respectively; P=0.57). CONCLUSION: There are no significant differences in cutaneous microvascular reactivity between patients with FMS and control subjects. |
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Authors:
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A W Al-Allaf; F Khan; J Moreland; J J Belch; T Pullar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 40 ISSN: 1462-0324 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-15 Completed Date: 2001-12-04 Revised Date: 2007-09-06 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 1097-101 Citation Subset: AIM; IM |
Affiliation:
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Rheumatic Disease Unit, University Department of Medicine, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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diagnostic use Adult Female Fibromyalgia / physiopathology* Humans Iontophoresis Male Microcirculation / physiology Middle Aged Nerve Fibers / physiology Nitroprusside / diagnostic use Nociceptors / drug effects, physiology Regional Blood Flow / drug effects, physiology Skin / blood supply*, innervation Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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