| Investigation of biochemical and haematological side-effects of enrofloxacin in dogs. | |
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MedLine Citation:
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PMID: 11515313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, effects of enrofloxacin on biochemical, haematological and blood gas parameters were investigated. Changes in laboratory parameters were monitored during the treatment period. Enrofloxacin was administered (5 mg/kg intramuscularly, once daily) to 10 healthy dogs for 14 days. Acidosis and temporary increases in aspartate aminotransferase, indirect bilirubin, sodium, partial pressure of CO2 and mean corpuscular volume levels as well as decreased levels of inorganic phosphorus, ionized calcium, potassium, partial pressure of O2 and standard bicarbonate were observed. The results of this study suggest that these observed effects of enrofloxacin on blood gas parameters should be taken into consideration in long-term use of the drug. |
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Authors:
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B Traş; M Maden; A L Baş; M Elmas; E Yazar; T Civelek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine Volume: 48 ISSN: 0931-184X ISO Abbreviation: J Vet Med A Physiol Pathol Clin Med Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-08-22 Completed Date: 2001-10-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100955112 Medline TA: J Vet Med A Physiol Pathol Clin Med Country: Germany |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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chemically induced,
veterinary Animals Anti-Infective Agents / adverse effects* Aspartate Aminotransferases / metabolism Bilirubin / analysis Blood Gas Analysis / veterinary* Dog Diseases / chemically induced* Dogs Female Fluoroquinolones* Quinolones / adverse effects* Sodium / analysis |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Quinolones; 635-65-4/Bilirubin; 7440-23-5/Sodium; 93106-60-6/enrofloxacin; EC 2.6.1.1/Aspartate Aminotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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