Document Detail

Investigation of bilirubin removal by NK-110 resin hemoperfusion in jaundiced dogs.
MedLine Citation:
PMID:  3781664     Owner:  NLM     Status:  MEDLINE    
A jaundiced dog model was made by common bile duct-inferior vena cava shunt with a silicon rubber tube. Blood bilirubin levels increased from 0.25 +/- 0.16 (SD) mg% to 15 +/- 1.4 (SD) mg%. These dog models were treated with a column containing 200 gm of macroreticular resin NK-110 which was linked between the femoral artery and vein. The rate of blood flow through the column was 200 ml/min. It was shown that total bilirubin reduced from 15 +/- 1.4 (SD) to 7.4 +/- 0.61 (SD), conjugated bilirubin decreased from 6.97 +/- 0.63 to 3.5 +/- 0.33 (SD) and unconjugated bilirubin from 7.8 +/- 2.1 to 4.2 +/- 0.4 (SD). There were no significant changes in protein, electrolyte, blood gases and acid base balance. Results show that NK-110 resin has good blood-compatible and adsorption properties.
S Ji-Chang; Q Shao-Cheng; Z Chen-Yang; N Fu-Hua; H Shao-Ming; L Tao; C Run-Hai; C Chang-Zhi; T Ming-Rong; W Hui-Ming
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  9     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1987-01-16     Completed Date:  1987-01-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
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MeSH Terms
Bilirubin / metabolism*
Disease Models, Animal
Ion Exchange Resins
Jaundice / therapy*
Resins, Synthetic*
Reg. No./Substance:
0/Ion Exchange Resins; 0/Polystyrenes; 0/Resins, Synthetic; 106717-05-9/NK 110 resin; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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