Document Detail


Investigation of beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR).
MedLine Citation:
PMID:  15856381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We could not detect hetero-vancomycin-intermediate resistant Staphylococcus aureus (hetero-VISA), according to the definition of hetero-VISA, from the clinical isolates of 140 methicillin-resistant S. aureus (MRSA) strains. However, 15 beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) strains were detected from the same strains. We screened 1882 MRSA clinical isolates obtained in 2002 from 21 institutes throughout Japan. The detection rate of blood-isolated BIVR was 12.6% (19/151), and that of nonblood-isolated BIVR was 4.9% (85/1731; P < 0.001; chi2 test). Uridine-diphosphate-N-acetylmuramyl-L: -alanyl-D: -isoglutamyl-L: -lysine, used as the peptidoglycan material of S. aureus, showed the same results as beta-lactam antibiotics in BIVR.
Authors:
Hideaki Hanaki; Yoshio Yamaguchi; Chie Yanagisawa; Kazuaki Uehara; Hidehito Matsui; Yukie Yamaguchi; Yasuko Hososaka; Kazunari Barada; Fumiko Sakai; Yasuko Itabashi; Shinsuke Ikeda; Koichiro Atsuda; Haruo Tanaka; Takashi Inamatsu; Ariaki Nagayama; Keisuke Sunakawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     Volume:  11     ISSN:  1341-321X     ISO Abbreviation:  J. Infect. Chemother.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2005-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9608375     Medline TA:  J Infect Chemother     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  104-6     Citation Subset:  IM    
Affiliation:
Research Center for Anti-infective Drugs, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-0072, Japan. hanaki@lisci.kitasato-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Methicillin Resistance*
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects*
Vancomycin Resistance*
beta-Lactams / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/beta-Lactams

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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