Document Detail

Investigation of an autologous blood treatment strategy for temporomandibular joint hypermobility in a pig model.
MedLine Citation:
PMID:  22867740     Owner:  NLM     Status:  MEDLINE    
Many different surgical and non-surgical techniques are used for the treatment of temporomandibular joint (TMJ) hypermobility. One of these methods is autologous blood injection into the TMJ. The fate of the autologous blood used for treatment of recurring condylar dislocation is still not completely understood. The authors used 12 pigs (Sus scrota f. domestica) as a model species for autologous blood delivery into the TMJ. Blood injection was followed by histopathological analysis at different times after treatment (1h, 1, 2 and 4 weeks). Samples were examined by magnetic resonance imaging, macroscopic and histological methods. The deposition of the remaining blood was observed in the form of clots in the distal parts of the upper joint cavity 1h and 1 week after treatment. 2 weeks after treatment, small blood clots were still apparent in the distal part of the upper joint cavity. 4 weeks after surgery, no remnants of blood, changes or adhesions were apparent inside the TMJ. No morphological or histological changes were observed in the TMJ after the injection of autologous blood suggesting another mechanism is involved in the hypermobility treatment.
J Stembirek; E Matalova; M Buchtova; V Machon; I Misek
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-04
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  42     ISSN:  1399-0020     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-08-26     Revised Date:  2014-07-14    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  D; IM    
Copyright Information:
Published by Elsevier Ltd.
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MeSH Terms
Blood / metabolism
Blood Coagulation
Blood Transfusion, Autologous / methods*
Disease Models, Animal
Dislocations / metabolism,  therapy*
Injections, Intra-Articular
Longitudinal Studies
Sus scrofa
Synovial Fluid / metabolism*
Temporomandibular Joint / metabolism*
Temporomandibular Joint Disorders / therapy*
Comment In:
Int J Oral Maxillofac Surg. 2013 Nov;42(11):1499   [PMID:  23796821 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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