Document Detail

Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat.
MedLine Citation:
PMID:  18323320     Owner:  NLM     Status:  MEDLINE    
The purpose of our study was to investigate the anxiolytic effects of linalool and its potential interaction with the GABAA receptor in Sprague-Dawley rats. Lavender has been used traditionally as an herbal remedy in the treatment of many medical conditions, including anxiety. Linalool is a major component of the essential oil of lavender. Forty-four rats were divided into 4 groups: control, linalool, midazolam (positive control), and flumazenil and linalool. The behavioral and the neurohormonal/physiological components of anxiety were evaluated. The behavioral component was examined by using the elevated plus maze (open arm time/total time) and the neurohormonal/physiological component by measuring serum catecholamine and corticosterone levels. Data analysis was performed using a 2-tailed Multivariate Analysis of Variance and Sheffe post-hoc test. Our data suggest that linalool does not produce anxiolysis by modulation of the GABAA receptor; however, linalool may modulate motor movements and locomotion.
Michael Cline; John E Taylor; Jesus Flores; Samuel Bracken; Suzanne McCall; Thomas E Ceremuga
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AANA journal     Volume:  76     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  N    
US Army Graduate Program in Anesthesia Nursing, William Beaumont Army Medical Center, El Paso, Texas, USA.
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MeSH Terms
Anti-Anxiety Agents / pharmacology,  therapeutic use*
Antidotes / therapeutic use
Anxiety / blood,  drug therapy*,  psychology
Behavior, Animal / drug effects
Disease Models, Animal
Drug Evaluation, Preclinical
Epinephrine / blood
Flumazenil / therapeutic use
GABA Modulators / therapeutic use
Locomotion / drug effects
Maze Learning / drug effects
Midazolam / therapeutic use
Monoterpenes / pharmacology,  therapeutic use*
Motor Skills / drug effects
Multivariate Analysis
Norepinephrine / blood
Phytotherapy / methods*
Plant Extracts / pharmacology,  therapeutic use*
Rats, Sprague-Dawley
Receptors, GABA-A / drug effects
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Antidotes; 0/GABA Modulators; 0/Monoterpenes; 0/Plant Extracts; 0/Receptors, GABA-A; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 59467-70-8/Midazolam; 78-70-6/linalool; 78755-81-4/Flumazenil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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