| Investigation of antiphosphatidyl-serine antibody and antiphosphatidyl-inositol antibody in ischemic stroke patients. | |
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MedLine Citation:
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PMID: 21197449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antiphospholipid syndrome is characterized by arterial or venous thrombosis and the presence of antiphospholipid antibodies (aPL). We measured β2-GPI aCL, IgGaCL, LA, antiphosphatidyl-serine antibody (PS), and antiphosphatidyl-inositol antibody (PI) in each patient at one month after the onset of stroke. In addition, carotid artery echography was performed in patients positive for PI or PS. Among the 250 patients, 13.6% (34/250) were positive for either PI or PS, and 6.8% (17/250) were positive for both. Carotid artery echography performed on these 34 patients showed that the frequencies of increased intimal-medial thickness (IMT) of 1.1 mm or more, plaque, and carotid artery stenosis of 50% or more were all significantly higher in patients positive for antinuclear antibody than those negative for the antibody (P < .05). PI and PS are associated with antinuclear antibody and precipitation of atherosclerosis. Ischemic stroke patients with SLE frequently showed a variety of antiphospholipid-protein antibodies. |
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Authors:
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Hirohisa Okuma; Yasuhisa Kitagawa; Shigeharu Takagi |
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Publication Detail:
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Type: Journal Article Date: 2010-12-20 |
Journal Detail:
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Title: Clinical & developmental immunology Volume: 2010 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2010 |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-06-21 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 439230 Citation Subset: IM |
Affiliation:
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Department of Neurology, Tokai University Tokyo Hospital, Tokyo 151-0053, Japan. ookuma@tok.u-tokai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antibodies, Antinuclear / blood Antibodies, Antiphospholipid / blood* Carotid Arteries / pathology Cerebral Infarction / blood, complications, immunology*, pathology Clinical Trials as Topic Female Humans Japan Lupus Erythematosus, Systemic / complications, immunology Male Middle Aged Phosphatidylinositols / immunology* Phosphatidylserines / immunology* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Antibodies, Antiphospholipid; 0/Phosphatidylinositols; 0/Phosphatidylserines |
| Comments/Corrections | |
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