Document Detail


Investigation of angiogenetic pathways in nasal polyposis.
MedLine Citation:
PMID:  22395195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue angiogenesis is a complex phenomenon that results in the growth of new blood vessels from the microcirculation. This process has been known to play a crucial role in tumor growth as well as several benign diseases. The aim of this study was to assess mRNA expression of various angiogenic factors and chemokines in nasal polyps and compare the results to normal nasal mucosa. mRNA expression was measured using real-time RT-PCR for the following angiogenic factors and chemokines: VEGF, VEGFR-1, Ang-1, Ang-2, Tie-2A, Tie-2B, SDF-1α, SDF-1β, CXCR4 and YY1. Biopsy specimens from nasal polyps in the polyposis group and middle turbinates in the control group were studied. A total of 18 nasal polyposis patients were studied and compared to 10 control subjects. Results showed VEGF, VEGFR-1, Ang-1, Ang-2, Tie-2A, Tie-2B, SDF-1α and SDF-1β mRNA expression to be significantly higher in nasal polyposis patients compared to the control group (p<0.05). The findings of this study support the role of angiogenic growth factors in the pathogenesis of nasal polyposis. Further studies are required to confirm these results and evaluate potential clinical implications.
Authors:
Alexandros D Karatzanis; Katerina D Samara; Katerina M Antoniou; Rena Lymbouridou; Nikolaos Chatzakis; Demetrios A Spandidos; Georgios A Velegrakis; Nikolaos M Siafakas
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Publication Detail:
Type:  Journal Article     Date:  2012-03-01
Journal Detail:
Title:  Molecular medicine reports     Volume:  5     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-07-03     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1158-62     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular and Cellular Pulmonary Medicine, Medical School, University of Crete, Heraklion, Crete, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cytokines / biosynthesis*
Female
Gene Expression Regulation*
Humans
Male
Middle Aged
Nasal Polyps / metabolism*,  pathology,  physiopathology
Neovascularization, Pathologic / metabolism*,  pathology,  physiopathology
RNA, Messenger / biosynthesis*
Chemical
Reg. No./Substance:
0/Cytokines; 0/RNA, Messenger

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