| Investigation of STW 5 (Iberogast®) preventive effects in experimental sepsis. | |
| | |
MedLine Citation:
|
PMID: 23336345 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Context: STW 5 (Iberogast(®)) is a well known herbal combination drug containing glycosides and flavonoids for which multiple pharmacological properties have been shown. Objective: In this study, attempts were made to assess whether STW 5, an aqueous ethanol solution, has a preventive effect against liver and lung pathological damage in rats after experimental induction of sepsis [cecal ligation and puncture (CLP)]. Materials and methods: Experimental sepsis was induced in rats using CLP operation. The rats (n = 36) were divided into six groups (six/group): Sham-operated (SOP); CLP; CLP + STW 5 (2.5, 5 and 10 mg/kg) and CLP + indomethacin. The drugs were injected intraperitoneally immediately after sepsis induction. Results: It was found that induction of sepsis 24 h after CLP was associated with significant liver and lung damage, also remaining after STW 5 administration. Discussion and conclusion: It appears that STW 5, which has a pronounced efficacy in functional gastro-intestinal diseases, has no effect on septic liver and lung damage in the CLP rat model. |
| | |
Authors:
|
A Dadkhah; F Fatemi; J Ashrafihelan |
Related Documents
:
|
22918985 - Acute stress, but not corticosterone, disrupts short- and long-term synaptic plasticity... 23462455 - The effects of hyperbaric oxygen application against cholestatic oxidative stress and h... 23105905 - Effect of lecithin and silymarin on d-galactosamine induced toxicity in isolated hepato... 23511125 - Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate in... 19783775 - Allogenic stem cell therapy improves right ventricular function by improving lung patho... 10699655 - Evaluation of the spontaneously hypertensive rat as a model of attention deficit hypera... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
|
Title: Pharmaceutical biology Volume: - ISSN: 1744-5116 ISO Abbreviation: Pharm Biol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9812552 Medline TA: Pharm Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Faculty of Medicine, Qom Branch, Islamic Azad University , Qom , Iran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Promoting value in dementia care: Staff, resident and family experience of the capabilities model of...
Next Document: Fatal Mycobacterium colombiense/cytomegalovirus coinfection associated with acquired immunodeficienc...