Document Detail

Investigation of STW 5 (Iberogast®) preventive effects in experimental sepsis.
MedLine Citation:
PMID:  23336345     Owner:  NLM     Status:  Publisher    
Context: STW 5 (Iberogast(®)) is a well known herbal combination drug containing glycosides and flavonoids for which multiple pharmacological properties have been shown. Objective: In this study, attempts were made to assess whether STW 5, an aqueous ethanol solution, has a preventive effect against liver and lung pathological damage in rats after experimental induction of sepsis [cecal ligation and puncture (CLP)]. Materials and methods: Experimental sepsis was induced in rats using CLP operation. The rats (n = 36) were divided into six groups (six/group): Sham-operated (SOP); CLP; CLP + STW 5 (2.5, 5 and 10 mg/kg) and CLP + indomethacin. The drugs were injected intraperitoneally immediately after sepsis induction. Results: It was found that induction of sepsis 24 h after CLP was associated with significant liver and lung damage, also remaining after STW 5 administration. Discussion and conclusion: It appears that STW 5, which has a pronounced efficacy in functional gastro-intestinal diseases, has no effect on septic liver and lung damage in the CLP rat model.
A Dadkhah; F Fatemi; J Ashrafihelan
Related Documents :
22918985 - Acute stress, but not corticosterone, disrupts short- and long-term synaptic plasticity...
24696425 - Hepatoprotective effects of zataria multiflora ethanolic extract on liver toxicity indu...
24887065 - Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypob...
23462455 - The effects of hyperbaric oxygen application against cholestatic oxidative stress and h...
19783775 - Allogenic stem cell therapy improves right ventricular function by improving lung patho...
10699655 - Evaluation of the spontaneously hypertensive rat as a model of attention deficit hypera...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Pharmaceutical biology     Volume:  -     ISSN:  1744-5116     ISO Abbreviation:  Pharm Biol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812552     Medline TA:  Pharm Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Medicine, Qom Branch, Islamic Azad University , Qom , Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Promoting value in dementia care: Staff, resident and family experience of the capabilities model of...
Next Document:  Fatal Mycobacterium colombiense/cytomegalovirus coinfection associated with acquired immunodeficienc...