| Investigation of SERPINE1 genetic polymorphism in Macedonian patients with occlusive artery disease and deep vein thrombosis. | |
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MedLine Citation:
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PMID: 20017074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Raised SERPINE1 plasma levels are related to a 1-bp guanine deletion/insertion (4G5G) polymorphism in the promoter of the SERPINE1 (plasminogen activator inhibitor 1 - PAI1) gene. Evidence suggested that the plasma levels of SERPINE1 modulate the risk of coronary artery disease; furthermore, that the 4G5G polymorphism affects the expression of the SERPINE1 gene. AIM: To analyse association of SERPINE1 polymorphism with occlusive artery disease (OAD) and deep venous thrombosis (DVT) in Macedonians in order to investigate its role as a part of candidate genes in different vascular diseases in Macedonians. METHODS: Investigated groups consisted of 82 healthy patients, 75 with OAD, and 66 with DVT. Blood samples were collected after written informed consent was obtained, and DNA was isolated from peripheral blood leukocytes. Identification of SERPINE1 polymorphism was done with CVD StripAssay (ViennaLab, Labordiagnostica GmbH, Austria). The population genetics analysis package, PyPop, was used for analysis of the SERPINE1 data. Pearson's P-values, crude odds ratio and Wald's 95% CI were calculated with Bonferroni corrected p value. RESULTS: The frequency of 4G allele for SERPINE1 was 0.538 for DVT, 0.555 for healthy participants, and 0.607 for OAD. The frequency of 5G allele for SERPINE1 was the smallest in patients with OAD (0.393) and was higher in healthy participants (0.445), and patients with DVT (0.462). Test of neutrality (Fnd) showed negative value, but was significantly different from 0 for SERPINE1 in healthy participants (p of F = 0.041) and in patients with DVT (p of F = 0.030). SERPINE1 genotypes in healthy participants and patients with OAD were not in Hardy Weinberg proportions (p = 0.019 and 0.001, respectively). No association between SERPINE1 polymorphisms and OAD or DVT was found. CONCLUSION: There is no significant relationship between SERPINE1 polymorphisms and occlusive artery disease or deep venous thrombosis in Macedonian population. |
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Authors:
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Igor Spiroski; Sashko Kedev; Slobodan Antov; Dejan Trajkov; Aleksandar Petlichkovski; Sloboda Dzhekova-Stojkova; Stojanka Kostovska; Mirko Spiroski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Kardiologia polska Volume: 67 ISSN: 0022-9032 ISO Abbreviation: Kardiol Pol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-04-09 Revised Date: 2010-04-19 |
Medline Journal Info:
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Nlm Unique ID: 0376352 Medline TA: Kardiol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 1088-94 Citation Subset: IM |
Affiliation:
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Clinic of Cardiology, Faculty of Medicine, Ss. Cyril and Methodius University, Blvd. Krste Petkov Misirkov bb, 1000 Skopje, Republic of Macedonia. ispiroski@gmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arterial Occlusive Diseases / genetics* Case-Control Studies European Continental Ancestry Group / genetics Female Gene Frequency / genetics Humans Macedonia (Republic) Male Middle Aged Plasminogen Activator Inhibitor 1 / genetics* Polymorphism, Genetic / genetics* Polymorphism, Single Nucleotide Risk Factors Venous Thrombosis / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Plasminogen Activator Inhibitor 1; 0/SERPINE1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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