| Investigation on Huntington's disease in the Canadian Prairies. II. Fecundity and fitness. | |
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MedLine Citation:
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PMID: 123838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The reproductive performance of 157 patients with Huntington's disease, their 170 normal siblings and 150 matched unrelated controls is presented. Comparison with the general Canadian Prairie population in the appropriate age group is undertaken. Patients with Huntington's disease are not only more fecund than their unaffected sibs but also out-reproduce unrelated normal controls and members of the general population of corresponding age. Their fitness is thus estimated to be 1.14. Should the present reproductive pattern continue, the allele for Huntington's disease will double its frequency with consequent doubling of the prevalence of the disorder in six generations or approximately 150 years' time. |
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Authors:
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M H Shokeir |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical genetics Volume: 7 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1975-07-18 Completed Date: 1975-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: DENMARK |
Other Details:
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Languages: eng Pagination: 349-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fertility Humans Huntington Disease / genetics* Male Sex Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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