| Investigation of the Factors that Contribute to the Onset of Insomnia in Hypertensive Patients by Using a Post-marketing Surveillance Database. | |
| | |
MedLine Citation:
|
PMID: 21532263 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Many factors contribute to the onset of insomnia. However, few studies have identified the factors related to the onset of insomnia in hypertensive patients. We conducted a pharmacoepidemiologic study to examine the incidence of insomnia in hypertensive patients by using a post-marketing surveillance database. The insomnia onset was defined as the time of first prescription of hypnotics. The insomnia incidence rate in hypertensive patients under antihypertensive therapy was 0.77/100 person-years. The median insomnia onset date was 5 weeks. The insomnia type in 50.2% of the patients was difficulty in initiating sleep. We assessed the factors contributing to insomnia by using a nested case-control design. We selected 10 time-matched controls for every case. The hypotensive effect induced by antihypertensive therapy on the case group was lesser than that on the control group (p<0.01). The odds ratios (ORs) were estimated using multivariate conditional logistic regression. The factors contributing to insomnia onset were α blockers (OR, 2.38; 95% confidence interval [CI], 1.14-4.98), β blockers (OR, 1.54; 95% CI, 0.99-2.39), and calcium channel blockers (OR, 0.62; 95% CI, 0.43-0.90) compared with angiotensin-converting enzyme inhibitors; female sex (OR, 1.76; 95% CI, 1.27-2.44); complication of gastric/duodenal disorders (OR, 2.35; 95% CI, 1.14-4.86) or musculoskeletal system/connective tissue disorders (OR, 2.43; 95% CI, 1.23-4.79); and concomitant antihypertensive therapy (OR, 0.44; 95% CI, 0.31-0.63). This study identified the potential factors that may help to predict insomnia onset in hypertensive patients under antihypertensive therapy. |
| | |
Authors:
|
Naoto Tanabe; Toshiharu Fujita; Yosuke Fujii; Takao Orii |
Related Documents
:
|
21532853 - Apolipoprotein b is highly associated with the risk of coronary heart disease as estima... 21146823 - Four genetic polymorphisms of paraoxonase gene and risk of coronary heart disease: a me... 16284373 - Interindividual variation in nucleotide excision repair genes and risk of endometrial c... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 131 ISSN: 1347-5231 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
|
Languages: eng Pagination: 669-77 Citation Subset: IM |
Affiliation:
|
Department of Pharmacy, NTT Medical Center Tokyo. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of the Nitric Oxide on Relaxation of the Human Umbilical Artery during Cooling.
Next Document: Furanocoumarins Contents and Cytochrome P450 3A (CYP3A) Inhibitory Activities of Various Processed F...